细胞学状态与病变大小：宫颈上皮内瘤变的另一个维度。

Cytological status and lesion size: a further dimension in cervical intraepithelial neoplasia.

作者信息

Jarmulowicz M R, Jenkins D, Barton S E, Goodall A L, Hollingworth A, Singer A

机构信息

Department of Histopathology, Whittington Hospital, Highgate Hill, London.

出版信息

Br J Obstet Gynaecol. 1989 Sep;96(9):1061-6. doi: 10.1111/j.1471-0528.1989.tb03381.x.

DOI:10.1111/j.1471-0528.1989.tb03381.x

PMID:2804008

Abstract

Quantitative histological study of 84 laser cone biopsies showed a highly significant correlation between the grade of a cervical smear and the size of the lesion for all grades of cervical intraepithelial neoplasia (CIN) (CIN I P = 0.004; CIN II P = 0.0001; CIN III P = 0.003; total CIN P less than 0.0001); 10 of 34 (29%) of women with CIN III and mild dyskaryosis or less had significantly smaller lesions than 23 of 36 (63%) of women with CIN III and moderate or severe dyskaryosis. Repeat cytology identified as severe dyskaryosis all those with large CIN III lesions. Lesion size has been neglected in studies of the natural history of CIN and in the assessment of cytological screening, but offers an explanation for the apparent discrepancies between cytological, colposcopic and histological assessment of progression of CIN.

摘要

对84例激光锥形活检组织进行的定量组织学研究表明，对于所有级别的宫颈上皮内瘤变（CIN），宫颈涂片分级与病变大小之间存在高度显著的相关性（CIN I，P = 0.004；CIN II，P = 0.0001；CIN III，P = 0.003；总CIN，P < 0.0001）；在34例CIN III且有轻度核异质或更轻病变的女性中，有10例（29%）的病变明显小于36例CIN III且有中度或重度核异质女性中的23例（63%）。重复细胞学检查将所有有大的CIN III病变的患者诊断为重度核异质。在CIN自然史研究和细胞学筛查评估中，病变大小一直被忽视，但它为CIN进展的细胞学、阴道镜和组织学评估之间明显的差异提供了解释。