Bosch Thomas C G, Klimovich Alexander, Domazet-Lošo Tomislav, Gründer Stefan, Holstein Thomas W, Jékely Gáspár, Miller David J, Murillo-Rincon Andrea P, Rentzsch Fabian, Richards Gemma S, Schröder Katja, Technau Ulrich, Yuste Rafael
University of Kiel, Kiel, Germany.
University of Kiel, Kiel, Germany.
Trends Neurosci. 2017 Feb;40(2):92-105. doi: 10.1016/j.tins.2016.11.005. Epub 2016 Dec 30.
The nervous systems of cnidarians, pre-bilaterian animals that diverged close to the base of the metazoan radiation, are structurally simple and thus have great potential to reveal fundamental principles of neural circuits. Unfortunately, cnidarians have thus far been relatively intractable to electrophysiological and genetic techniques and consequently have been largely passed over by neurobiologists. However, recent advances in molecular and imaging methods are fueling a renaissance of interest in and research into cnidarians nervous systems. Here, we review current knowledge on the nervous systems of cnidarian species and propose that researchers should seize this opportunity and undertake the study of members of this phylum as strategic experimental systems with great basic and translational relevance for neuroscience.
刺胞动物是后生动物辐射演化基部附近分化出来的前两侧对称动物，其神经系统结构简单，因此在揭示神经回路的基本原理方面具有巨大潜力。不幸的是，到目前为止，刺胞动物对电生理和遗传技术来说相对难以处理，因此在很大程度上被神经生物学家忽视了。然而，分子和成像方法的最新进展正在激发人们对刺胞动物神经系统的兴趣并推动相关研究的复兴。在这里，我们综述了关于刺胞动物物种神经系统的现有知识，并建议研究人员应抓住这个机会，将这一门类的成员作为对神经科学具有重大基础和转化意义的战略实验系统来进行研究。
