Ramos-Martinez Juan Ignacio
Department of Biochemistry and Molecular Biology, School of Veterinary, University of Santiago de Compostela, Campus Terra, Lugo E-27002, Spain.
Arch Biochem Biophys. 2017 Jan 15;614:50-52. doi: 10.1016/j.abb.2016.12.012. Epub 2016 Dec 30.
The changes in gene expression and posttranslational modifications of enzymes are comprised in the concept of "coarse control" of the oxidative phase of the pentose phosphate pathway. However, these changes are slow in its implementation. The defensive mechanism against oxidative stress requires a most rapid response, impossible to achieve with coarse regulation systems. Recently, it has been suggested that a quick acceleration mechanism of G6PD activity could be produced by the reduction of NADPH-inhibition of G6PD. The hypothesis opens new ways on possible mechanisms for rapid modulation that could be in accordance with results obtained in the 70s by Krebs. These results seemed outdated in view of the subsequent research. However, they deserve to be re-assessed at present.
戊糖磷酸途径氧化阶段“粗调控”的概念包括基因表达的变化和酶的翻译后修饰。然而，这些变化在实施过程中很缓慢。针对氧化应激的防御机制需要最快速的反应，而粗调控系统无法实现这一点。最近，有人提出，G6PD活性的快速加速机制可能是由NADPH对G6PD抑制作用的减弱所产生的。这一假设为可能符合70年代Krebs所获得结果的快速调节机制开辟了新途径。鉴于后续研究，这些结果似乎过时了。然而，目前它们值得重新评估。
