Grauffel V, Kloareg B, Mabeau S, Durand P, Jozefonvicz J
Laboratoire de Recherches sur les Macromolécules, CNRS UA 502, Université Paris-Nord, Villetaneuse, France.
Biomaterials. 1989 Aug;10(6):363-8. doi: 10.1016/0142-9612(89)90127-0.
Fucans extracted from brown algae exhibit anticoagulant properties, as demonstrated by coagulation assays and kinetic study of the inactivation of thrombin in the presence of antithrombin III. These derivatives exert a direct antithrombic activity by an antithrombin III-independent pathway. Besides, their anticoagulant activity is not mediated by a potency to inhibit factor Xa. Relatively low-molecular-mass fractions (50,000 Daltons) prepared by chromatographic fractionation of the crude fucans also exhibit anticoagulant activity. They may prove useful as anticoagulant drugs.
从褐藻中提取的岩藻聚糖具有抗凝特性，这在凝血试验以及抗凝血酶III存在时凝血酶失活的动力学研究中得到了证实。这些衍生物通过一条不依赖抗凝血酶III的途径发挥直接的抗血栓形成活性。此外，它们的抗凝活性并非由抑制因子Xa的能力介导。通过对粗制岩藻聚糖进行色谱分离制备的相对低分子量级分（50,000道尔顿）也表现出抗凝活性。它们可能被证明是有用的抗凝血药物。
