Kose Eiji, Maruyama Riku, Okazoe Susumu, Hayashi Hiroyuki
Department of Pharmacotherapy, School of Pharmacy, Nihon University, Chiba, Japan.
Department of Pharmacy, Sagami Rehabilitation Hospital, Kanagawa, Japan.
J Aging Res. 2016;2016:7957825. doi: 10.1155/2016/7957825. Epub 2016 Nov 29.
. A risk factor associated with stroke onset is chronic kidney disease (CKD). To prevent stroke reoccurrence, it is necessary to strictly manage blood pressure, lipids, and plasma glucose. Therefore, some cases are forced to polypharmacy, elderly patients in particular. Polypharmacy often leads to adverse drug reactions and has the potential to negatively affect the rehabilitation of stroke patients. The aim of the present study was to investigate the effects of polypharmacy using a functional independence measure (FIM). . A total of 144 stroke patients with CKD were included in the present analysis. We divided stroke patients into those taking six or more drugs (polypharmacy group) and those taking less than six drugs (nonpolypharmacy group) upon admission. Patient background features, laboratory data, and FIM scores were compared. . FIM-Motor (FIM-M) efficiency, age, and diabetes mellitus were positively associated with polypharmacy. FIM-M efficiency in the polypharmacy group was significantly lower than in the nonpolypharmacy group. . Polypharmacy interferes with the effect of rehabilitation in stroke patients with CKD. Pharmacists and doctors should make efforts to optimize medications to be able to respond to the outcome of each patient.
与中风发病相关的一个风险因素是慢性肾脏病（CKD）。为预防中风复发，严格管理血压、血脂和血糖很有必要。因此，一些病例尤其是老年患者被迫使用多种药物。使用多种药物常常会导致药物不良反应，并有可能对中风患者的康复产生负面影响。本研究的目的是使用功能独立性测量（FIM）来调查使用多种药物的影响。本分析共纳入了144例患有CKD的中风患者。我们将中风患者在入院时分为服用六种或更多药物的患者（多种药物组）和服用少于六种药物的患者（非多种药物组）。比较了患者的背景特征、实验室数据和FIM评分。FIM运动（FIM-M）效率、年龄和糖尿病与使用多种药物呈正相关。多种药物组的FIM-M效率显著低于非多种药物组。使用多种药物会干扰患有CKD的中风患者的康复效果。药剂师和医生应努力优化用药，以便能够应对每位患者的情况。
