Impact of Chronic Obstructive Pulmonary Disease on Long-Term Outcome in Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention.

. The aim of this study was to investigate the association between COPD and major adverse cardiovascular and cerebral events (MACCE) in patients undergoing percutaneous coronary intervention (PCI). . 2,362 patients who underwent PCI were included in this study. Subjects were divided into 2 groups: with COPD ( = 233) and without COPD ( = 2,129). Cox proportional hazards models were analyzed to determine the effect of COPD on the incidence of MACCE. . The patients with COPD were older ( < 0.0001) and were more likely to be current smokers ( = 0.02) and have had hypertension ( = 0.02) and diabetes mellitus ( = 0.01). Prevalence of serious cardiovascular comorbidity was higher in the patients with COPD, including a history of MI ( = 0.02) and HF ( < 0.0001). Compared with non-COPD group, the COPD group showed a higher risk of all-cause death (hazard ratio (HR): 2.45, < 0.0001), cardiac death (HR: 2.53, = 0.0002), MI (HR: 1.387, = 0.027), and HF (HR: 2.25, < 0.0001). . Patients with CAD and concomitant COPD are associated with a higher incidence of MACCE (all-cause death, cardiac death, MI, and HF) compared to patients without COPD. The patients with a history of COPD have higher in-hospital and long-term mortality rates than those without COPD after PCI.