Quisenberry Amanda J, Snider Sarah E, Bickel Warren K
Addiction Recovery Research Center, Virginia Tech Carilion Research Institute, Roanoke, VA.
Behav Anal (Wash D C). 2016 Nov;16(4):215-220. doi: 10.1037/bar0000042.
Rate dependence, a well-known phenomenon in behavioral pharmacology, appears to have declined as a topic of interest, perhaps, as a result of being viewed pertinent to only the preclinical investigation of drugs on schedule-controlled performance. Obstacles to data interpretation due to conflation with regression to the mean also appear to have contributed to the topic's decline. Despite this reduction in exposure, rate dependence is a useful concept and tool that can be used to determine sources of variability, predict therapeutic outcomes, and identify individuals that are most likely to respond therapeutically. Armed with new statistical methods and an understanding of the broad range of conditions under which rate dependence can be observed, we urge researchers to revisit the concept, use the appropriate analysis methods, and to design empirical studies to further explore rate dependence.
速率依赖性是行为药理学中一个广为人知的现象，作为一个感兴趣的话题，它似乎已经不再受关注，这可能是因为它被认为仅与药物对按时间表控制的行为表现的临床前研究相关。由于与均值回归相混淆而导致的数据解释障碍似乎也促使了该话题的热度下降。尽管对它的关注减少了，但速率依赖性仍是一个有用的概念和工具，可用于确定变异性的来源、预测治疗结果以及识别最有可能产生治疗反应的个体。有了新的统计方法以及对可观察到速率依赖性的广泛条件的理解，我们敦促研究人员重新审视这一概念，使用适当的分析方法，并设计实证研究以进一步探索速率依赖性。
