Kazanova E G, Shchelkunova T A, Smirnov A N, Rozen V B
Biull Eksp Biol Med. 1989 Aug;108(8):221-4.
Tissue distribution in male and female rats of unusual immunoreactive material specific for the hepatic estrogen-binding protein (UEBP) was studied by means of immunoblotting analysis. From 28 organs and tissues studied only the liver of animals of both sexes was found to contain polypeptide with Mr, close to Mr of purified UEBP (approximately 31,000), which reacts with anti-UEBP specific antiserum. Detection of the immunoreactive material in female liver, which does not contain any hormone-binding activity of UEBP, suggests pre- or posttranslational modifications of the protein. It is concluded that the regulatory action of UEBP on steroid biodynamics bears a narrow-directed, organ-specific character.
通过免疫印迹分析研究了雄性和雌性大鼠中对肝雌激素结合蛋白（UEBP）具有特异性的异常免疫反应性物质的组织分布。在所研究的28个器官和组织中，仅发现两性动物的肝脏含有分子量与纯化的UEBP（约31,000）相近的多肽，该多肽能与抗UEBP特异性抗血清发生反应。在不具有UEBP任何激素结合活性的雌性肝脏中检测到免疫反应性物质，提示该蛋白存在翻译前或翻译后修饰。得出的结论是，UEBP对类固醇生物动力学的调节作用具有狭窄定向、器官特异性的特征。
