亨廷顿舞蹈病感觉运动网络中与睡眠相关的脑电图连接性改变：一项脑电逆推断层成像（eLORETA）研究及文献综述
Sleep-related modifications of EEG connectivity in the sensory-motor networks in Huntington Disease: An eLORETA study and review of the literature.
作者信息
Piano Carla, Imperatori Claudio, Losurdo Anna, Bentivoglio Anna Rita, Cortelli Pietro, Della Marca Giacomo
机构信息
Center for Parkinson Disease and Extrapyramidal Disorders, Movement Disorders Unit, Institute of Neurology, Catholic University, Rome, Italy; Department of Biomedical and NeuroMotor Sciences (DIBINEM), Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Department of Human Sciences, European University, Rome, Italy.
出版信息
Clin Neurophysiol. 2017 Jul;128(7):1354-1363. doi: 10.1016/j.clinph.2016.11.019. Epub 2016 Dec 5.
OBJECTIVE
To evaluate EEG functional connectivity in the sensory-motor network, during wake and sleep, in patients with Huntington Disease (HD).
METHODS
23 patients with HD and 23 age- and sex-matched healthy controls were enrolled. EEG connectivity analysis was performed by means of exact Low Resolution Electric Tomography (eLORETA).
RESULTS
In wake, HD patients showed an increase of delta lagged phase synchronization (T=3.60; p<0.05) among Broadman's Areas (BA) 6-8 bilaterally; right BA 6-8 and right BA 1-2-3; left BA 1-2-3 and left BA 4. In NREM, HD patients showed an increase of delta lagged phase synchronization (T=3.56; p<0.05) among left BA 1-2-3 and right BA 6-8. In REM, HD patients showed an increase of lagged phase synchronization (T=3.60; p<0.05) among the BA 6-8 bilaterally (delta band); left BA 1-2-3 and right BA 1-2-3 (theta); left BA 1-2-3 and right BA 4 (theta); left BA 1-2-3 and right BA 1-2-3 (alpha).
CONCLUSIONS
Our results may reflect an abnormal function of the motor areas or an effort to counterbalance the pathological motor output.
SIGNIFICANCE
Our results may help to understand the pathophysiology of sleep-related movement disorders in Huntington's Disease, and to define therapeutically strategies.
目的
评估亨廷顿舞蹈症（HD）患者在清醒和睡眠状态下感觉运动网络中的脑电图功能连接性。
方法
招募了23名HD患者以及23名年龄和性别匹配的健康对照者。通过精确低分辨率脑电断层扫描（eLORETA）进行脑电图连接性分析。
结果
在清醒状态下，HD患者双侧布罗德曼区（BA）6 - 8之间的δ波滞后相位同步增加（T = 3.60；p < 0.05）；右侧BA 6 - 8与右侧BA 1 - 2 - 3之间；左侧BA 1 - 2 - 3与左侧BA 4之间。在非快速眼动睡眠（NREM）状态下，HD患者左侧BA 1 - 2 - 3与右侧BA 6 - 8之间的δ波滞后相位同步增加（T = 3.56；p < 0.05）。在快速眼动睡眠（REM）状态下，HD患者双侧BA 6 - 8之间（δ波段）、左侧BA 1 - 2 - 3与右侧BA 1 - 2 - 3之间（θ波段）、左侧BA 1 - 2 - 3与右侧BA 4之间（θ波段）、左侧BA 1 - 2 - 3与右侧BA 1 - 2 - 3之间（α波段）的滞后相位同步增加（T = 3.60；p < 0.05）。
结论
我们的结果可能反映了运动区域的异常功能或对病理性运动输出进行平衡的努力。
意义
我们的结果可能有助于理解亨廷顿舞蹈症中与睡眠相关的运动障碍的病理生理学，并确定治疗策略。
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