卡地内酯J - M，来自韩国被囊动物伪瘤海鞘的抗菌多苯基丁烯内酯。
Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja.
作者信息
Wang Weihong, Kim Hiyoung, Patil Rahul S, Giri Awadut G, Won Dong Hwan, Hahn Dongyup, Sung Youjung, Lee Jusung, Choi Hyukjae, Nam Sang-Jip, Kang Heonjoong
机构信息
Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Republic of Korea.
College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyeongsan 38541, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2017 Feb 1;27(3):574-577. doi: 10.1016/j.bmcl.2016.12.016. Epub 2016 Dec 7.
Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J-M, 1, 3-5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.
对被囊动物伪瘤海鞘进行活性导向分离，得到了四种新的卡地内酯类化合物（卡地内酯J - M，1, 3 - 5）以及一种已知化合物（卡地内酯H，2）。通过包括X射线晶体学分析在内的光谱方法确定了这些化合物的结构。对这些化合物的抗菌活性进行了评估，结果显示它们对所有测试的耐药菌株均表现出强效抗菌活性，其最低抑菌浓度与万古霉素和利奈唑胺等市售药物相当。
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