Wang Ruijia, OuYang Yuejun, Xu Chonghui, Yi Niannian, Jiang Jun, Deng Wei, Zeng Zebing, Xiang Jiannan
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, P. R. China.
Huaihua Key Laboratory of Functional Inorganic & Polymaterial Materials (Huaihua University), Huaihua 418000, P. R. China.
Org Biomol Chem. 2017 Jan 25;15(4):796-800. doi: 10.1039/c6ob02536f.
A novel hypervalent iodine-triggered hydroamination of homopropargyl sulfonamides with copper halides to obtain dihalo-2,3-dihydropyrroles was efficiently developed. The reaction can provide access to chloro/bromo-cyclization extended from iodocyclization to prepare potentially useful halogenated building blocks for drug development with broad functional group tolerance and high yield yet in a short time.
