Fujita Koji, Iwama Hisakazu, Oura Kyoko, Tadokoro Tomoko, Samukawa Eri, Sakamoto Teppei, Nomura Takako, Tani Joji, Yoneyama Hirohito, Morishita Asahiro, Himoto Takashi, Hirashima Mitsuomi, Masaki Tsutomu
Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, Ikenobe 1750-1, Miki, Kita, Kagawa 761-0793, Japan.
Life Science Research Center, Kagawa University, Ikenobe 1750-1, Miki, Kita, Kagawa 761-0793, Japan.
Int J Mol Sci. 2017 Jan 1;18(1):74. doi: 10.3390/ijms18010074.
Dysregulation of apoptosis is a major hallmark in cancer biology that might equip tumors with a higher malignant potential and chemoresistance. The anti-cancer activities of lectin, defined as a carbohydrate-binding protein that is not an enzyme or antibody, have been investigated for over a century. Recently, galectin-9, which has two distinct carbohydrate recognition domains connected by a linker peptide, was noted to induce apoptosis in thymocytes and immune cells. The apoptosis of these cells contributes to the development and regulation of acquired immunity. Furthermore, human recombinant galectin-9, hG9NC (null), which lacks an entire region of the linker peptide, was designed to resist proteolysis. The hG9NC (null) has demonstrated anti-cancer activities, including inducing apoptosis in hematological, dermatological and gastrointestinal malignancies. In this review, the molecular characteristics, history and apoptosis-inducing potential of galectin-9 are described.
细胞凋亡失调是癌症生物学的一个主要标志，它可能使肿瘤具有更高的恶性潜能和化疗耐药性。凝集素被定义为一种非酶或抗体的碳水化合物结合蛋白，其抗癌活性已被研究了一个多世纪。最近，半乳糖凝集素-9被发现可诱导胸腺细胞和免疫细胞凋亡，它有两个由连接肽连接的不同碳水化合物识别结构域。这些细胞的凋亡有助于获得性免疫的发育和调节。此外，人重组半乳糖凝集素-9（hG9NC，无连接肽）被设计用于抵抗蛋白水解。hG9NC（无连接肽）已显示出抗癌活性，包括诱导血液学、皮肤病学和胃肠道恶性肿瘤细胞凋亡。在这篇综述中，我们描述了半乳糖凝集素-9的分子特征、历史及诱导凋亡的潜能。
