阿片类药物成瘾的神经药理学概述
A Brief Overview of the Neuropharmacology of Opioid Addiction.
作者信息
Grothusen John R, Blendy Julie A, Barr Gordon A
机构信息
Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Transl Perioper Pain Med. 2022;9(4):491-496. doi: 10.31480/2330-4871/165. Epub 2022 Dec 5.
The world is in the midst of an opioid crisis. Nearly 92,000 persons in the U.S. alone died from illicit drugs and prescription opioids in 2020 [1]. This number does not include the countless other individuals who die as a result of the violent crime that accompanies the illicit drug trade. To address this crisis, we need to appreciate aspects of drug addiction. The goal of this brief review is to highlight some major facets of addiction neurobiology, focused on opioids, to provide a basic understanding of the research and terminology encountered in more detailed in-depth articles and discussions on addiction.
世界正处于阿片类药物危机之中。仅在2020年，美国就有近9.2万人死于非法药物和处方阿片类药物[1]。这个数字还不包括因非法毒品交易伴随的暴力犯罪而死亡的无数其他个体。为应对这一危机，我们需要了解药物成瘾的各个方面。本简要综述的目的是突出成瘾神经生物学的一些主要方面，重点是阿片类药物，以便对在关于成瘾的更详细深入的文章和讨论中遇到的研究和术语有一个基本的了解。
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