Peel S, Stewart I
J Anat. 1984 Dec;139 ( Pt 4)(Pt 4):593-8.
The differentiation of granulated metrial gland (GMG) cells has been investigated during deciduomata formation in radiation-induced chimeric mice reconstituted with rat or mouse bone marrow. The extent of the decidual reaction was apparently normal in regions of the uterine horns shielded from the irradiation but was impaired in, or absent from, the irradiated horns. The numbers of GMG cells which differentiated varied but were greater in the larger decidual swellings. The distinct morphological differences between rat and mouse GMG cells were used to analyse the GMG cells which differentiated in mice reconstituted with rat bone marrow. Only rat GMG cells were identified in the unshielded horns showing that bone marrow cells provide precursors for GMG cells. However, both rat and mouse GMG cells were found in the horns shielded from the irradiation. This indicates that some precursors for mouse GMG cells are present in the uterus at the time of the irradiation and are protected by the lead shield to survive and differentiate in situ. Furthermore they do not circulate to replace the precursors killed in the unshielded horn.
在由大鼠或小鼠骨髓重建的辐射诱导嵌合小鼠蜕膜形成过程中，对颗粒状蜕膜腺（GMG）细胞的分化进行了研究。在子宫角未受辐射的区域，蜕膜反应的程度显然正常，但在受辐射的子宫角中，蜕膜反应受损或不存在。分化的GMG细胞数量各不相同，但在较大的蜕膜肿胀中数量更多。利用大鼠和小鼠GMG细胞之间明显的形态学差异，对用大鼠骨髓重建的小鼠中分化的GMG细胞进行分析。在未受保护的子宫角中仅鉴定出大鼠GMG细胞，这表明骨髓细胞为GMG细胞提供前体。然而，在未受辐射的子宫角中发现了大鼠和小鼠GMG细胞。这表明在照射时子宫中存在一些小鼠GMG细胞的前体，并且这些前体受到铅屏蔽的保护得以存活并在原位分化。此外，它们不会循环以替代在未受保护的子宫角中被杀死的前体。
