Chłopecka Magdalena, Mendel Marta, Dziekan Natalia, Karlik Wojciech
Warsaw University of Life Sciences, Faculty of Veterinary Medicine, Department of Preclinical Sciences, Division of Pharmacology and Toxicology, 8, Ciszewskiego St.,02-786 Warsaw, Poland.
Warsaw University of Life Sciences, Faculty of Veterinary Medicine, Department of Preclinical Sciences, Division of Pharmacology and Toxicology, 8, Ciszewskiego St.,02-786 Warsaw, Poland.
Environ Toxicol Pharmacol. 2017 Jan;49:156-162. doi: 10.1016/j.etap.2016.12.010. Epub 2016 Dec 26.
The study was aimed at evaluating the effect of Roundup, polyoxyethylene tallow amine (POEA) and mixture of glyphosate and POEA in different levels on the motoric activity of jejunum strips. The incubation in the Roundup solutions caused a significant, mostly miorelaxant, reversible reaction of smooth muscle; only in the highest tested dose which is equivalent to the agricultural concentration (1% corresponding to 1.7g glyphosate/L) there was an irreversible disturbance of the spontaneous contractility and reactivity. The incubation in POEA solutions in the range of low doses (0.256; 1.28; 6.4mg/L) resulted in a biphasic muscle reaction (relaxation and contraction); whereas in the range of high doses, i.e. 32; 160 and 800mg/L (agricultural spray concentrations) induced only a miorelaxant, irreversible response. The results indicate very high toxicity of POEA which exceeds the toxicity of the commercial formulations. Besides, it is postulated that glyphosate and POEA may display antagonistic interaction towards the motoric activity of gastrointestinal tract.
该研究旨在评估不同浓度的草甘膦除草剂、聚氧乙烯牛脂胺（POEA）以及草甘膦与POEA的混合物对空肠肌条运动活性的影响。在草甘膦除草剂溶液中孵育会引起平滑肌显著的、大多为舒张性的、可逆反应；仅在最高测试剂量（相当于农业浓度，1%相当于1.7克草甘膦/升）下，会出现自发性收缩性和反应性的不可逆紊乱。在低剂量范围（0.256；1.28；6.4毫克/升）的POEA溶液中孵育会导致肌肉出现双相反应（舒张和收缩）；而在高剂量范围，即32；160和800毫克/升（农业喷雾浓度）下，仅诱导出舒张性的、不可逆反应。结果表明POEA具有非常高的毒性，超过了商业配方的毒性。此外，据推测草甘膦和POEA可能对胃肠道的运动活性表现出拮抗作用。
