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实施肠内营养方案对危重症成年患者肠内营养改善情况的影响。

The impact of implementation of an enteral feeding protocol on the improvement of enteral nutrition in critically ill adults.

作者信息

Kim Seoung-Hyun, Park Chi-Min, Seo Jeong-Meen, Choi Mingew, Lee Dae-Sang, Chang Dong Kyung, Rha Miyong, Yu Soyoung, Lee Seonhye, Kim Eunmee, Cho Young Yun

机构信息

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Email:

出版信息

Asia Pac J Clin Nutr. 2017 Jan;26(1):27-35. doi: 10.6133/apjcn.122015.01.

Abstract

BACKGROUND AND OBJECTIVES

The optimal delivery of enteral nutrition (EN) may improve clinical outcomes in critically ill patients; thus, optimal EN protocols should be developed. The purpose of this study was to evaluate the impact of implementing an EN protocol on the improvement of EN practices and on the clinical outcomes of critically ill patients.

METHODS AND STUDY DESIGN

This was a retrospective study with prospectively collected data. Multidisciplinary working group developed an evidence-based EN protocol based on an extensive review of literature and existing guidelines. Subjects included patients consecutively admitted to the ICU who received EN for more than 24 hours. EN practices and clinical outcomes were compared before and after implementation of the protocol.

RESULTS

A total of 270 patients were included, 134 patients before implementation and 136 after implementation of the protocol. EN was initiated earlier (35.8 vs 87.1 hours, p=0.001) and more patients received EN within 24 hours (59.6% vs 41.0%, p=0.002) after implementation of the protocol. The interval between starting EN and reaching the caloric goal was not different, but more patients reached the caloric goal after implementation (52.2% vs 38.3%, p=0.037). The post-implementation group was given more prokinetics and less parenteral nutrition. The incidences of diarrhea and gastrointestinal bleeding significantly decreased following implementation of the protocol. There was no difference in clinical outcomes including in-hospital mortality and length of hospital and ICU stay.

CONCLUSION

The implementation of the EN protocol significantly improved the practices of EN and decreased complications in critically ill patients. Clinical outcomes were not different before and after implementation.

摘要

背景与目的

肠内营养(EN)的优化输送可能改善危重症患者的临床结局;因此,应制定最佳EN方案。本研究的目的是评估实施EN方案对改善EN实践以及危重症患者临床结局的影响。

方法与研究设计

这是一项回顾性研究,数据前瞻性收集。多学科工作组基于对文献和现有指南的广泛回顾制定了循证EN方案。研究对象包括连续入住ICU且接受EN超过24小时的患者。比较方案实施前后的EN实践和临床结局。

结果

共纳入270例患者,方案实施前134例,实施后136例。方案实施后,EN开始时间更早(35.8小时对87.1小时,p=0.001),更多患者在24小时内接受EN(59.6%对41.0%,p=0.002)。开始EN至达到热量目标的间隔无差异,但实施后更多患者达到热量目标(52.2%对38.3%,p=0.037)。实施后组给予更多促动力药且肠外营养更少。方案实施后腹泻和胃肠道出血的发生率显著降低。包括住院死亡率、住院时间和ICU住院时间在内的临床结局无差异。

结论

EN方案的实施显著改善了EN实践并降低了危重症患者的并发症。实施前后临床结局无差异。

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