Mao Qi-Qi, Lin Yi-Wei, Chen Hong, Qin Jie, Zheng Xiang-Yi, Xu Xin, Xie Li-Ping
Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China. Email:
Department of Urology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Asia Pac J Clin Nutr. 2017 Jan;26(1):89-96. doi: 10.6133/apjcn.102015.03.
The association between fiber intake and pancreatic cancer risk is conflicting and poorly explored. The aim of study was to investigate the association between dietary fiber intake and the risk of pancreatic cancer by conducting a meta-analysis of epidemiological studies.
Systematic search of PubMed and Embase databases up to April 2015 were conducted to identify relevant studies. Adjusted odds ratios (ORs) were combined using random-effects models to assess the risk of pancreatic cancer when comparing extreme categories of fiber intake. Dose-response meta-analysis was performed for studies reporting categorical risk estimates for at least 3 exposure levels.
One cohort and thirteen case-control studies were identified. The overall analysis revealed a strong inverse association between risk of pancreatic cancer and high fiber intake (OR 0.52; 95% CI 0.44-0.61). No publication bias was detected by Egger's or Begg's test. The dose-response analyses showed that the summary OR for an increment of 10 g daily intake of fiber was 0.88 (0.84 to 0.92).
A high intake of dietary fiber was associated with a reduced risk of pancreatic cancer. Further well-designed prospective studies are warranted to confirm the inverse association and to identify the dietary fiber types involved.
膳食纤维摄入量与胰腺癌风险之间的关联存在争议且研究较少。本研究旨在通过对流行病学研究进行荟萃分析，探讨膳食纤维摄入量与胰腺癌风险之间的关联。
对截至2015年4月的PubMed和Embase数据库进行系统检索，以识别相关研究。在比较膳食纤维摄入量的极端类别时，使用随机效应模型合并调整后的比值比（OR），以评估胰腺癌风险。对报告至少3个暴露水平的分类风险估计的研究进行剂量反应荟萃分析。
确定了1项队列研究和13项病例对照研究。总体分析显示，胰腺癌风险与高膳食纤维摄入量之间存在强烈的负相关（OR 0.52；95%CI 0.44-0.61）。Egger检验或Begg检验未检测到发表偏倚。剂量反应分析表明，每日膳食纤维摄入量增加10克的汇总OR为0.88（0.84至0.92）。
高膳食纤维摄入量与降低胰腺癌风险相关。需要进一步设计良好的前瞻性研究来证实这种负相关，并确定所涉及的膳食纤维类型。
