Li Li-yi, Luo Yue, Lu Ming-dong, Xu Xiao-wu, Lin Hai-duo, Zheng Zhi-qiang
Department of General Surgery, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325027, China.
Department of Pediatrics, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
World J Surg Oncol. 2015 Feb 12;13:44. doi: 10.1186/s12957-015-0454-4.
Previous studies regarding the association between cruciferous vegetable intake and pancreatic cancer risk have reported inconsistent results. We conducted a meta-analysis to demonstrate the potential association between them.
A systematic literature search of papers was conducted in March 2014 using PubMed, EMBASE, and Web of Science, and the references of the retrieved articles were screened. The summary odds ratios (ORs) with 95% confidence interval (CI) for the highest versus the lowest intake of cruciferous vegetables were calculated.
Four cohort and five case-control studies were eligible for inclusion. We found a significantly decreased risk of pancreatic cancer associated with the high intake of cruciferous vegetables (OR 0.78, 95% CI 0.64-0.91). Moderate heterogeneity was detected across studies (P = 0.065). There was no evidence of significant publication bias based on Begg's funnel plot (P = 0.917) or Egger's test (P = 0.669).
Cruciferous vegetable intake might be inversely associated with pancreatic cancer risk. Because of the limited number of studies included in this meta-analysis, further well-designed prospective studies are warranted to confirm the inverse association between cruciferous vegetable intake and risk of pancreatic cancer.
以往关于十字花科蔬菜摄入量与胰腺癌风险之间关联的研究报告结果并不一致。我们进行了一项荟萃分析以证明它们之间的潜在关联。
2014年3月使用PubMed、EMBASE和Web of Science对论文进行了系统的文献检索，并筛选了检索文章的参考文献。计算了十字花科蔬菜最高摄入量与最低摄入量相比的汇总比值比（OR）及其95%置信区间（CI）。
四项队列研究和五项病例对照研究符合纳入标准。我们发现十字花科蔬菜高摄入量与胰腺癌风险显著降低相关（OR 0.78，95%CI 0.64 - 0.91）。各研究间检测到中度异质性（P = 0.065）。基于Begg漏斗图（P = 0.917）或Egger检验（P = 0.669），没有证据表明存在显著的发表偏倚。
十字花科蔬菜摄入量可能与胰腺癌风险呈负相关。由于本荟萃分析纳入的研究数量有限，有必要进行进一步设计良好的前瞻性研究以证实十字花科蔬菜摄入量与胰腺癌风险之间的负相关关系。
