Honma T, Bang D, Saito T, Nakagawa S, Ueki H
Department of Pharmacology, Kawasaki Medical School, Japan.
J Submicrosc Cytol Pathol. 1989 Oct;21(4):691-701.
Biopsy specimens of recurrent erythema nodosum-like lesions from corticosteroid-treated and non-treated patients with Behçet's syndrome were examined with the electron microscope to determine the incidence of apoptotic cell death of infiltrating lymphocytes in connective tissue. Apoptosis of infiltrating lymphocytes was detected in all corticosteroid-treated patients, but not in non-treated patients. While part of this phenomenon is undoubtedly due to a direct action of corticosteroids on the lymphocytes themselves, it seems likely that indirect action of the corticosteroids such as inhibition of lymphokine or interleukin production may deprive lymphocytes of proliferative and other stimuli and therefore also play some part in the overall response.
对接受皮质类固醇治疗和未接受治疗的白塞病患者复发性结节性红斑样病变的活检标本进行电子显微镜检查，以确定结缔组织中浸润淋巴细胞凋亡性细胞死亡的发生率。在所有接受皮质类固醇治疗的患者中均检测到浸润淋巴细胞的凋亡，但在未接受治疗的患者中未检测到。虽然这种现象部分无疑是由于皮质类固醇对淋巴细胞本身的直接作用，但皮质类固醇的间接作用，如抑制淋巴因子或白细胞介素的产生，似乎可能使淋巴细胞失去增殖和其他刺激，因此在整体反应中也起了一定作用。
