Bang D, Honma T, Saito T, Nakagawa S, Ueki H, Lee S
Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
J Toxicol Sci. 1987 Aug;12(3):321-8. doi: 10.2131/jts.12.321.
We used electron microscopy and electron microscopic X-ray spectroanalysis to examine the biopsies taken from erythema nodosum-like lesions of 20 patients with Behçet's disease. Electron-dense degenerated endothelial cells were found in the microcirculatory beds of the dermis and subcutaneous fat. However, electron microscopic X-ray spectroanalysis failed to demonstrate the localization of either chlorine or base metals in those degenerated endothelial cells. Moreover, neither in ultrastructurally normal endothelial cells, nor in infiltrating macrophages of erythema nodosum-like lesions the positive deposit of chlorine or base metals could not be detected. The results of this analysis suggest that environmental factors do not play an etiologic role in this disease. Significance of the degeneration of endothelial cells is not clear present.
我们使用电子显微镜和电子显微镜X射线光谱分析来检查从20例白塞病患者的结节性红斑样病变中获取的活检组织。在真皮和皮下脂肪的微循环床中发现了电子致密的变性内皮细胞。然而，电子显微镜X射线光谱分析未能证明氯或碱金属在这些变性内皮细胞中的定位。此外，在超微结构正常的内皮细胞中，以及在结节性红斑样病变的浸润巨噬细胞中，均未检测到氯或碱金属的阳性沉积。该分析结果表明环境因素在该疾病中不发挥病因学作用。目前尚不清楚内皮细胞变性的意义。
