Maurer F, Lorenz D J, Pielsticker G, Volk T, Sessler D I, Baumbach J I, Kreuer S
Center of Breath Research, Department of Anaesthesiology, Intensive Care and Pain Therapy, Saarland University Medical Center and Saarland University Faculty of Medicine, Building 57, D-66421 Homburg, Germany.
J Breath Res. 2017 Jan 23;11(1):016009. doi: 10.1088/1752-7163/aa567e.
Propofol is an intravenous anesthetic. Currently, it is not possible to routinely measure blood concentration of the drug in real time. However, multi-capillary column ion-mobility spectrometry of exhaled gas can estimate blood propofol concentration. Unfortunately, adhesion of volatile propofol on plastic materials complicates measurements. Therefore, it is necessary to consider the extent to which volatile propofol adheres to various plastics used in sampling tubing. Perfluoralkoxy (PFA), polytetrafluorethylene (PTFE), polyurethane (PUR), silicone, and Tygon tubing were investigated in an experimental setting using a calibration gas generator (HovaCAL). Propofol gas was measured for one hour at 26 °C, 50 °C, and 90 °C tubing temperature. Test tubing segments were then flushed with N to quantify desorption. PUR and Tygon sample tubing absorbed all volatile propofol. The silicone tubing reached the maximum propofol concentration after 119 min which was 29 min after propofol gas exposure stopped. The use of PFA or PTFE tubing produced comparable and reasonably accurate propofol measurements. The desaturation time for the PFA was 10 min shorter at 26 °C than for PTFE. PFA tubing thus seems most suitable for measurement of volatile propofol, with PTFE as an alternative.
丙泊酚是一种静脉麻醉剂。目前，尚无法实时常规测量该药物的血药浓度。然而，呼出气体的多毛细管柱离子迁移谱法可以估算血丙泊酚浓度。不幸的是，挥发性丙泊酚在塑料材料上的粘附使测量变得复杂。因此，有必要考虑挥发性丙泊酚在采样管中使用的各种塑料上的粘附程度。在实验环境中，使用校准气体发生器（HovaCAL）对全氟烷氧基（PFA）、聚四氟乙烯（PTFE）、聚氨酯（PUR）、硅树脂和泰贡管进行了研究。在26℃、50℃和90℃的管温下，对丙泊酚气体进行了1小时的测量。然后用氮气冲洗测试管段以量化解吸。PUR和泰贡采样管吸收了所有挥发性丙泊酚。硅树脂管在119分钟后达到丙泊酚最大浓度，这是在丙泊酚气体暴露停止后29分钟。使用PFA或PTFE管可获得相当且合理准确的丙泊酚测量结果。在26℃时，PFA的去饱和时间比PTFE短10分钟。因此，PFA管似乎最适合用于测量挥发性丙泊酚，PTFE可作为替代选择。
