Wirtz L M, Kreuer S, Volk T, Hüppe T
Center of Breath Research (CBR); Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum des Saarlandes, Kirrberger Straße 100, Gebäude 57, 66424, Homburg (Saar), Deutschland.
Med Klin Intensivmed Notfmed. 2019 Oct;114(7):655-660. doi: 10.1007/s00063-019-0544-0. Epub 2019 Feb 6.
Analysis of exhaled air is a risk-free option for bedside diagnostics. Modern breath analysis can detect very low concentrations of volatile components. Current research focuses on drug monitoring and diagnosis of various diseases.
Presentation and discussion of current breath research relevant to intensive care medicine.
The literature in PubMed was searched using the following terms: "breath analysis", "volatile organic compounds", "critically ill" combined with "drug monitoring", "propofol", "heart failure", "pneumonia", "ARDS", "renal failure", "liver failure", "sepsis" or "hemorrhage".
Intravenously administered propofol can now be measured reliably in exhaled air. Functional impairments of the heart, lungs, kidneys and liver show characteristic influences on the exhaled air, which could serve as a new diagnostic tool in the future. Animal experiments already show promising results to detect sepsis, hemorrhage and ventilator-induced lung injury.
In the future, modern breath analysis could enable non-invasive drug monitoring and diagnostics of medical conditions relevant to intensive care medicine.
呼气分析是一种用于床边诊断的无风险方法。现代呼吸分析能够检测到极低浓度的挥发性成分。当前的研究集中在药物监测和各种疾病的诊断上。
介绍和讨论与重症医学相关的当前呼吸研究。
在PubMed中使用以下检索词搜索文献：“呼吸分析”、“挥发性有机化合物”、“危重症患者”，并与“药物监测”、“丙泊酚”、“心力衰竭”、“肺炎”、“急性呼吸窘迫综合征”、“肾衰竭”、“肝衰竭”、“脓毒症”或“出血”相结合。
现在可以在呼出气体中可靠地测量静脉注射的丙泊酚。心脏、肺、肾和肝脏的功能损害对呼出气体有特征性影响，这在未来可能成为一种新的诊断工具。动物实验已经显示出在检测脓毒症、出血和呼吸机诱导的肺损伤方面有前景的结果。
未来，现代呼吸分析能够实现无创药物监测以及对与重症医学相关的病症进行诊断。
