Na Ga Yoon, Yoon So Ra, An Juhyun, Yeo Rimkyo, Song Juhyun, Jo Mi-Na, Han Seongho, Kim Oh Yoen
Department of Food Science and Nutrition, Dong-A University, Brain Busan 21 Project, Busan 49315, South Korea.
Endocr J. 2017 Mar 31;64(3):303-314. doi: 10.1507/endocrj.EJ16-0233. Epub 2016 Dec 30.
Circulating neutrophil gelatinase-associated lipocalin (NGAL) is associated with obesity-related metabolic disorders. This study investigated the relationship between serum NGAL and early alteration of metabolic parameters in non-diabetic Korean women, particularly with respect to saturated fat (SFA) intake. Anthropometric parameters, fasting glycemic status, and levels of lipids, oxidative stress/inflammatory markers, and NGAL were measured in 82 non-diabetic Korean women [Super-healthy group (n=57) with 0 metabolic syndrome risk factor (MetS RF) and MetS-risk group (n=25) with MetS RF≥1]. Age, weight, waist circumference, blood pressure, fasting glucose, HbA1C, triglyceride, LDL and total-cholesterol, and NGAL levels were higher, and HDL-cholesterol was lower in the MetS-risk group than in the Super-healthy group. Age-adjusted serum NGAL levels were higher in the MetS-risk group than in the Super-healthy group. NGAL increased proportionally with increase in MetS RFs (p=0.038) and correlated positively with BMI, triglycerides, LDL- and total-cholesterol, interleukin-6, white blood cell count, and neutrophil%, and negatively with HDL-cholesterol and superoxide dismutase activity. Serum NGAL levels positively correlated with SFA intake before and after adjustment (age and BMI). Serum NGAL levels were higher in high-SFA consumers [≥7g/day, ≥7% of total calorie intake (TCI)] than in low-SFA consumers (<7g/day, <7% of TCI). Serum NGAL levels were highest in the MetS-risk group consuming higher SFA and lowest in the Super-healthy group consuming lower SFA. However, serum NGAL did not significantly differ between the low-SFA consuming MetS-risk and Super-healthy groups. The relationship between circulating NGAL and early alteration of metabolic parameters is associated with dietary SFA intake in non-diabetic Korean women.
循环中性粒细胞明胶酶相关脂质运载蛋白（NGAL）与肥胖相关的代谢紊乱有关。本研究调查了非糖尿病韩国女性血清NGAL与代谢参数早期变化之间的关系，特别是关于饱和脂肪（SFA）摄入量方面。对82名非糖尿病韩国女性进行了人体测量参数、空腹血糖状态以及脂质、氧化应激/炎症标志物和NGAL水平的测量[超级健康组（n = 57），无代谢综合征风险因素（MetS RF）；MetS风险组（n = 25），MetS RF≥1]。与超级健康组相比，MetS风险组的年龄、体重、腰围、血压、空腹血糖、糖化血红蛋白、甘油三酯、低密度脂蛋白和总胆固醇以及NGAL水平更高，而高密度脂蛋白胆固醇更低。经年龄调整后，MetS风险组的血清NGAL水平高于超级健康组。NGAL随着MetS RFs的增加而成比例增加（p = 0.038），并与体重指数、甘油三酯、低密度脂蛋白和总胆固醇、白细胞介素-6、白细胞计数和中性粒细胞百分比呈正相关，与高密度脂蛋白胆固醇和超氧化物歧化酶活性呈负相关。调整前后（年龄和体重指数）血清NGAL水平与SFA摄入量呈正相关。高SFA消费者[≥7克/天，≥总热量摄入（TCI）的7%]的血清NGAL水平高于低SFA消费者（<7克/天，<TCI的7%）。在摄入较高SFA的MetS风险组中血清NGAL水平最高，在摄入较低SFA的超级健康组中最低。然而，低SFA摄入的MetS风险组和超级健康组之间血清NGAL没有显著差异。在非糖尿病韩国女性中，循环NGAL与代谢参数早期变化之间的关系与膳食SFA摄入量有关。
