Bhanja Atanu, D'Souza D S J
Assistant Professor, Dept of Dental Surgery, Sikkim Manipal Institute of Medical Sciences, Gangtok, India.
Professor & HOD, Dept of Dental Surgery, Sikkim Manipal Institute of Medical Sciences, Gangtok, India.
Med J Armed Forces India. 2016 Dec;72(Suppl 1):S24-S30. doi: 10.1016/j.mjafi.2016.05.004. Epub 2016 Jun 14.
Research into finding the perfect replacement for lost dentition is an ever-evolving and rapidly advancing subject involving many scientific disciplines. The present consensus appears to be that regeneration of tooth in morphological and functional form is the ideal answer to lost tooth replacement. This article traces the milestones in this elusive search for the ultimate tooth replacement. The various research developments are highlighted that are aimed at the final goal of being able to "re-grow a natural tooth". Whole tooth regeneration is technically challenging and further research into this field of complex molecular biology, embryology, biomaterials and stem cells is required to answer the unsolved questions. However, the milestones that have been crossed in the attempts at whole tooth regeneration have been remarkable and the future is quite promising. This article highlights the noteworthy research work that is being done in the field of whole tooth regeneration with a view to not only inform the clinicians of the significant developments but also inspire them to actively participate in this rapidly evolving field.
寻找缺失牙完美替代物的研究是一个不断发展且迅速推进的课题，涉及许多科学学科。目前的共识似乎是，以形态和功能形式再生牙齿是缺失牙替代的理想解决方案。本文追溯了在这一难以捉摸的寻找终极牙齿替代物过程中的里程碑。重点介绍了旨在实现“重新长出天然牙齿”这一最终目标的各种研究进展。全牙再生在技术上具有挑战性，需要对复杂的分子生物学、胚胎学、生物材料和干细胞领域进行进一步研究，以回答尚未解决的问题。然而，在全牙再生尝试中所跨越的里程碑意义非凡，未来充满希望。本文重点介绍了全牙再生领域正在进行的值得关注的研究工作，不仅是为了让临床医生了解重大进展，也是为了激励他们积极参与这个迅速发展的领域。
