Sushil Mishra Indira, Muneshwar J N, Afroz Sayeeda
Postgraduate Resident, Department of Physiology, GMC , Aurangabad, Maharashtra, India .
Associate Professor, Department of Physiology, GMC , Aurangabad, Maharashtra, India .
J Clin Diagn Res. 2016 Nov;10(11):CC01-CC04. doi: 10.7860/JCDR/2016/19336.8791. Epub 2016 Nov 1.
Neuropathy is one of the commonest complications of Diabetes Mellitus (DM). Apart from having peripheral and autonomic neuropathy patients with type 2 DM may also suffer from sensory neural hearing loss, which is more severe at higher frequencies. However, few studies have done detailed evaluation of sensory pathway in these patients. In this study brain stem auditory evoked potential is used to detect the acoustic and central neuropathy in a group of patients with type 2 DM with controlled and uncontrolled blood sugar.
To study brain stem auditory evoked potential in patients of type 2 DM with controlled and uncontrolled blood sugar and to correlate the various parameters e.g., age (years), weight (kilograms), height (meters), BMI (kg/m), HbA1c (%) in patients with type 2 DM with controlled and uncontrolled blood sugar.
Cross-sectional comparative study conducted from January 2014 to January 2015. Total 60 patients with type 2 DM of either sex, between age groups of 35-50 years were enrolled from the Diabetic Clinic of Medicine department, of a tertiary care hospital. Based on the value of HbA1c, patients were divided in two groups with controlled and uncontrolled blood sugar and with each group comprising of 30 patients. BERA (Brainstem Evoked Response Audiometry) was done in both the groups on RMS ALERON 201/401. Recordings were taken at 70dB, 80dB and 90dB at 2KHz frequency. Absolute latency of wave I, III, V and interpeak latencies I-III, III-V and I-V were recorded.
Mean±SD of the absolute latency of BERA waves I, III, V and interpeak latencies I-III, III-V and I-V at 2 KHz and at varying intensity of 70dB, 80dB and 90dB in uncontrolled group of DM were delayed and were significant as compared to controlled group of DM.
If BERA is done in diabetic patients, central neuropathy can be detected earlier in uncontrolled groups of diabetic patients.
神经病变是糖尿病（DM）最常见的并发症之一。除了周围神经病变和自主神经病变外，2型糖尿病患者还可能患有感觉神经性听力损失，在高频时更为严重。然而，很少有研究对这些患者的感觉通路进行详细评估。在本研究中，使用脑干听觉诱发电位来检测一组血糖控制良好和控制不佳的2型糖尿病患者的听觉和中枢神经病变。
研究血糖控制良好和控制不佳的2型糖尿病患者的脑干听觉诱发电位，并将2型糖尿病患者血糖控制良好和控制不佳组的各种参数，如年龄（岁）、体重（千克）、身高（米）、体重指数（kg/m）、糖化血红蛋白（%）进行关联分析。
2014年1月至2015年1月进行横断面比较研究。从一家三级护理医院内科糖尿病诊所招募了60例年龄在35 - 50岁之间的2型糖尿病患者，男女不限。根据糖化血红蛋白值，将患者分为血糖控制良好组和控制不佳组，每组30例。两组均在RMS ALERON 201/401上进行脑干听觉诱发电位（BERA）检测。在2KHz频率下，分别于70dB、80dB和90dB强度下进行记录。记录波I、III、V的绝对潜伏期以及峰间期I - III、III - V和I - V。
在2KHz频率下，糖尿病控制不佳组在70dB、80dB和90dB不同强度时，BERA波I、III、V的绝对潜伏期以及峰间期I - III、III - V和I - V的均值±标准差均延迟，与糖尿病控制良好组相比差异有统计学意义。
如果对糖尿病患者进行BERA检测，在糖尿病控制不佳组中可更早检测到中枢神经病变。
