Jha Indira, Alam Kabir, Keshari Kaushal K, Sinha Niska, Kumar Tarun
Department of Physiology, IGIMS, Patna, Bihar, India.
Department of Psychiatry, IGIMS, Patna, Bihar, India.
Adv Biomed Res. 2023 Jul 20;12:182. doi: 10.4103/abr.abr_418_22. eCollection 2023.
Hearing deterioration in hypothyroid subject was documented by Kemp. Cristiane . reported delayed waves latency in subclinical hypothyroid subjects. Recording of auditory brain stem evoked response in subclinical hypothyroid subjects at 80 dB and varying frequencies has been done.
Case control study. Group 1, N = 30 control subjects, free T3, free T4, thyroid stimulating hormone (TSH) within normal range. Group 2, = 30 subclinical hypothyroid subjects, TSH was between 4.6-8 microIU/L. Student Unpaired t test was done. Those on epileptic, neuroleptics, depression, psychosis drugs, inflammatory, proliferative, traumatic ear disorder, smokers, on tobacco, COVID-19 positive subjects, altered sensorium, drug abuse, diabetes mellitus, neuropathy, hypertension, cardiac arrhythmia, family history of hearing disorder, and furosemide drug were excluded. Auditory brainstem evoked response (ABER) done.
Mean ± SD of Brainstem evoked response auditory (BERA) waves III, V, interpeak latencies at 80 dB, 2, 4,6 KHz reported delay and significant in subclinical hypothyroid group as compared to control.
BERA study at 6 KHz and 80 dB detects central neuropathy earlier in subclinical hypothyroid patients.
肯普记录了甲状腺功能减退患者的听力减退情况。克里斯蒂安妮报告了亚临床甲状腺功能减退患者的波潜伏期延迟。已对亚临床甲状腺功能减退患者在80分贝和不同频率下进行听觉脑干诱发电位记录。
病例对照研究。第1组，N = 30名对照受试者，游离T3、游离T4、促甲状腺激素（TSH）在正常范围内。第2组， = 30名亚临床甲状腺功能减退受试者，TSH在4.6 - 8微国际单位/升之间。进行了学生非配对t检验。排除患有癫痫、使用抗精神病药、抑郁症、精神病药物、炎症性、增殖性、创伤性耳部疾病、吸烟者、吸食烟草者、新冠病毒检测呈阳性者、意识改变者、药物滥用者、糖尿病、神经病变、高血压、心律失常、有听力障碍家族史者以及使用速尿药物者。进行了听觉脑干诱发电位（ABER）检测。
与对照组相比，亚临床甲状腺功能减退组在80分贝、2、4、6千赫兹时脑干听觉诱发电位（BERA）波III、V的平均±标准差、峰间潜伏期报告有延迟且具有显著性。
在6千赫兹和80分贝下进行的BERA研究能更早地检测出亚临床甲状腺功能减退患者的中枢神经病变。
