Singh Garima, Singh Meeta, Chandana Mansi, Singh Sompal, Nargotra Namrata
Senior Resident, Department of Pathology, NDMC Medical College and Hindu Rao Hospital , Malka Ganj, Delhi, India .
Assistant Professor, NDMC Medical College and Hindu Rao Hospital , Malka Ganj, Delhi, India .
J Clin Diagn Res. 2016 Nov;10(11):ED12-ED13. doi: 10.7860/JCDR/2016/22038.8853. Epub 2016 Nov 1.
Inverted Papilloma (IP) is an uncommon and locally aggressive benign tumour of sinonasal region, which tends to recur after surgical resection. Most tumours are confined to the lateral nasal wall and sinuses, with maxillary sinus being most commonly affected and a male preponderance. It has a known association with and invasive carcinomas with a <10% rate of malignant transformation. Most common association has been seen with squamous cell carcinoma and extremely rare association with adenocarcinoma and small cell carcinoma. A 36-year-old male presented with a left sided polypoidal nasal mass and underwent a polypectomy. Pathology results showed IP with mild dysplasia. The polypoidal growth reappeared on the same side after a period of 10 months and on histopathological examination, the growth revealed features of intestinal type adenocarcinoma. IP recurring as adenocarcinoma is rare and even after exhaustive literature search only few cases could be found. Two studies have described recurrence of adenocarcinoma in existing IP previously. We report an unusual case of inverted papilloma showing malignant transformation into an intestinal type adenocarcinoma in a 36-year-old male patient within 10 months of previous surgery.
内翻性乳头状瘤(IP)是鼻窦区域一种罕见的、具有局部侵袭性的良性肿瘤,手术切除后易复发。大多数肿瘤局限于鼻侧壁和鼻窦,其中上颌窦最常受累,且男性居多。它与侵袭性癌有关,恶性转化率<10%。最常见的关联是与鳞状细胞癌,与腺癌和小细胞癌的关联极为罕见。一名36岁男性因左侧息肉样鼻肿物就诊并接受了息肉切除术。病理结果显示为伴有轻度发育异常的内翻性乳头状瘤。10个月后,息肉样肿物在同一侧再次出现,组织病理学检查显示该肿物具有肠型腺癌的特征。内翻性乳头状瘤复发为腺癌很罕见,即使经过详尽的文献检索也仅发现少数病例。此前有两项研究描述了现有内翻性乳头状瘤中腺癌的复发情况。我们报告了一例不寻常的病例,一名36岁男性患者在先前手术10个月内,内翻性乳头状瘤恶变成为肠型腺癌。