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SPO11-C631T基因多态性与男性不育风险：一项荟萃分析。

The SPO11-C631T gene polymorphism and male infertility risk: a meta-analysis.

作者信息

Ren Zheng-Ju, Ren Peng-Wei, Yang Bo, Liao Jian, Liu Sheng-Zhuo, Fang Kun, Ren Shang-Qing, Liu Liang-Ren, Dong Qiang

机构信息

a Department of Urology , Institute of Urology, West China Hospital, Sichuan University , Chengdu , Sichuan , China.

b Department of Evidence-Based Medicine and Clinical Epidemiology , West China Hospital, Sichuan University , Chengdu , Sichuan , China.

出版信息

Ren Fail. 2017 Nov;39(1):299-305. doi: 10.1080/0886022X.2016.1274661. Epub 2017 Jan 4.

DOI:10.1080/0886022X.2016.1274661
PMID:28050928
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6014381/
Abstract

To evaluate the association between the SPO11 gene C631T polymorphism and the risk of male infertility. We conducted a search on PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), China biology medical literature database (CBM), VIP, and Chinese literature database (Wan Fang) on 31 March 2016. Odds ratio (OR) and 95% confidence interval (95%CI) were used to assess the strength of associations. A total of five studies including 542 cases and 510 controls were involved in this meta-analysis. The pooled results indicated that the SPO11 gene C631T polymorphism was significantly associated with increased risk of male infertility (TT + CT vs. CC: OR = 4.14, 95%CI = 2.48-6.89; CT vs. CC: OR = 4.34, 95%CI = 2.56-7.34; T vs. C: OR = 4.35, 95%CI = 2.58-7.34). Subgroup analysis of different countries proved the relationship between SPO11 gene C631T polymorphism and male infertility risk in Chinese, but not in Iranian peoples. In conclusion, this study suggested that SPO11 gene C631T polymorphism may contribute as a genetic factor susceptible to cause male infertility. Furthermore, more large sample and representative population-based cases and well-matched controls are needed to validate our results.

摘要

为评估SPO11基因C631T多态性与男性不育风险之间的关联。我们于2016年3月31日在PubMed、Embase、Web of Science、中国知网（CNKI）、中国生物医学文献数据库（CBM）、维普资讯（VIP）和中文科技期刊数据库（万方）进行了检索。采用比值比（OR）和95%置信区间（95%CI）来评估关联强度。本荟萃分析共纳入五项研究，包括542例病例和510例对照。汇总结果表明，SPO11基因C631T多态性与男性不育风险增加显著相关（TT + CT vs. CC：OR = 4.14，95%CI = 2.48 - 6.89；CT vs. CC：OR = 4.34，95%CI = 2.56 - 7.34；T vs. C：OR = 4.35，95%CI = 2.58 - 7.34）。不同国家的亚组分析证实了SPO11基因C631T多态性与中国男性不育风险之间的关系，但在伊朗人群中未得到证实。总之，本研究提示SPO11基因C631T多态性可能是导致男性不育的一个易感遗传因素。此外，需要更多大样本、基于代表性人群的病例和匹配良好的对照来验证我们的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/a86dad58091b/IRNF_A_1274661_F0007_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/e37aca95ce4f/IRNF_A_1274661_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/9658e11aed7a/IRNF_A_1274661_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/1c872f388f6b/IRNF_A_1274661_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/66045c8696a4/IRNF_A_1274661_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/6ae3f910357c/IRNF_A_1274661_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/0981db7ec679/IRNF_A_1274661_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/a86dad58091b/IRNF_A_1274661_F0007_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/e37aca95ce4f/IRNF_A_1274661_F0001_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/9658e11aed7a/IRNF_A_1274661_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/1c872f388f6b/IRNF_A_1274661_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/66045c8696a4/IRNF_A_1274661_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/6ae3f910357c/IRNF_A_1274661_F0005_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/0981db7ec679/IRNF_A_1274661_F0006_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e418/6014381/a86dad58091b/IRNF_A_1274661_F0007_B.jpg

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4
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