Kentley J, Cerio R, Khorshid M, Gibbon K
Department of Dermatology, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.
Department of Cutaneous Medicine and Surgery, Royal London Hospital, Barts Health NHS Trust, London, UK.
Clin Exp Dermatol. 2017 Mar;42(2):189-191. doi: 10.1111/ced.13026. Epub 2017 Jan 4.
We report the case of a 24-year-old woman with an 8-month history of deep pelvic pain and postcoital bleeding. Examination revealed desquamation of the vaginal epithelium with tender fissured plaques in the vagina, initially thought to be vaginal intraepithelial neoplasia. Histology showed squamous mucosa with suprabasal acantholysis and hyperkeratosis, and no evidence of viral infection, dysplasia or malignancy. These findings were consistent with acantholytic dermatosis (AD), a rare lesion that resembles Hailey-Hailey and Darier disease histopathologically, but can be distinguished on a clinical basis. Vulval cases of AD are well recognized, but to our knowledge, this is the first reported case involving the vaginal epithelium alone.
我们报告了一例24岁女性病例，该患者有8个月的盆腔深部疼痛和性交后出血病史。检查发现阴道上皮脱屑，阴道内有触痛的裂隙状斑块，最初被认为是阴道上皮内瘤变。组织学检查显示鳞状黏膜有基底层上棘层松解和角化过度，且无病毒感染、发育异常或恶性肿瘤的证据。这些发现与棘层松解性皮肤病（AD）相符，这是一种罕见的病变，在组织病理学上类似于黑利-黑利病和毛囊角化病，但可在临床上加以区分。AD的外阴病例已广为人知，但据我们所知，这是首例仅累及阴道上皮的报告病例。
