Turner D P
Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, United States.
Adv Cancer Res. 2017;133:1-22. doi: 10.1016/bs.acr.2016.08.001. Epub 2016 Oct 12.
While the socioeconomic and environmental factors associated with cancer disparity have been well documented, the contribution of biological factors is an emerging field of research. Established disparity factors such as low income, poor diet, drinking alcohol, smoking, and a sedentary lifestyle may have molecular effects on the inherent biological makeup of the tumor itself, possibly altering cell signaling events and gene expression profiles to profoundly alter tumor development and progression. Our understanding of the molecular and biological consequences of poor lifestyle is lacking, but such information may significantly change how we approach goals to reduce cancer incidence and mortality rates within minority populations. In this review, we will summarize the biological, socioeconomic, and environmental associations between a group of reactive metabolites known as advanced glycation end-products (AGEs) and cancer health disparity. Due to their links with lifestyle and the activation of disease-associated pathways, AGEs may represent both a biological consequence and a bio-behavioral indicator of poor lifestyle which may be targeted within specific populations to reduce disparities in cancer incidence and mortality.
虽然与癌症差异相关的社会经济和环境因素已有充分记录，但生物因素的作用仍是一个新兴的研究领域。诸如低收入、不良饮食、饮酒、吸烟和久坐不动的生活方式等既定的差异因素可能会对肿瘤本身的内在生物学构成产生分子影响，可能改变细胞信号传导事件和基因表达谱，从而深刻改变肿瘤的发展和进程。我们对不良生活方式的分子和生物学后果了解不足，但此类信息可能会显著改变我们实现降低少数族裔人群癌症发病率和死亡率目标的方式。在本综述中，我们将总结一组称为晚期糖基化终产物（AGEs）的反应性代谢物与癌症健康差异之间的生物学、社会经济和环境关联。由于它们与生活方式以及疾病相关途径的激活存在联系，AGEs可能既代表了不良生活方式的生物学后果，也代表了生物行为指标，可针对特定人群进行干预，以减少癌症发病率和死亡率的差异。
