Van Doorslaer Koenraad, Li Zhiwen, Xirasagar Sandhya, Maes Piet, Kaminsky David, Liou David, Sun Qiang, Kaur Ramandeep, Huyen Yentram, McBride Alison A
DNA Tumor Virus Section, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 209892, USA.
Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 209892, USA.
Nucleic Acids Res. 2017 Jan 4;45(D1):D499-D506. doi: 10.1093/nar/gkw879. Epub 2016 Oct 5.
The Papillomavirus Episteme (PaVE) is a database of curated papillomavirus genomic sequences, accompanied by web-based sequence analysis tools. This update describes the addition of major new features. The papillomavirus genomes within PaVE have been further annotated, and now includes the major spliced mRNA transcripts. Viral genes and transcripts can be visualized on both linear and circular genome browsers. Evolutionary relationships among PaVE reference protein sequences can be analysed using multiple sequence alignments and phylogenetic trees. To assist in viral discovery, PaVE offers a typing tool; a simplified algorithm to determine whether a newly sequenced virus is novel. PaVE also now contains an image library containing gross clinical and histopathological images of papillomavirus infected lesions. Database URL: https://pave.niaid.nih.gov/.
乳头瘤病毒知识库（PaVE）是一个经过整理的乳头瘤病毒基因组序列数据库，并配有基于网络的序列分析工具。本次更新介绍了主要新功能的增加情况。PaVE中的乳头瘤病毒基因组已得到进一步注释，现在包括主要的剪接mRNA转录本。病毒基因和转录本可以在线性和环形基因组浏览器上可视化。可以使用多序列比对和系统发育树分析PaVE参考蛋白序列之间的进化关系。为协助病毒发现，PaVE提供了一个分型工具；这是一种用于确定新测序病毒是否为新病毒的简化算法。PaVE现在还包含一个图像库，其中包含乳头瘤病毒感染病变的大体临床和组织病理学图像。数据库网址：https://pave.niaid.nih.gov/ 。
