Marcu Laura, Hartl Brad A
University of California, Davis, Davis, CA 95616 USA.
IEEE J Sel Top Quantum Electron. 2012 Jul-Aug;18(4):1465-1477. doi: 10.1109/JSTQE.2012.2185823. Epub 2012 Jan 24.
Clinical outcome of patients diagnosed with primary brain tumor has been correlated with the extent of surgical resection. In treating this disease, the neurosurgeon must balance between an aggressive, radical resection and minimizing the loss of healthy, functionally significant brain tissue. Numerous intra-operative methodologies and technological approaches have been explored as a means to improve the accuracy of surgical resection. This paper presents an overview of current conventional techniques and new emerging technologies with potential to impact the area of image-guided surgery of brain tumors. Emphasis is placed on techniques based on endogenous fluorescence lifetime contrast and their potential for intraoperative diagnosis of brain tumors.
原发性脑肿瘤患者的临床结果与手术切除范围相关。在治疗这种疾病时，神经外科医生必须在积极的根治性切除与尽量减少健康且功能重要的脑组织损失之间取得平衡。人们探索了多种术中方法和技术手段，以提高手术切除的准确性。本文概述了当前的传统技术以及可能影响脑肿瘤图像引导手术领域的新兴技术。重点介绍了基于内源性荧光寿命对比的技术及其在脑肿瘤术中诊断方面的潜力。
