Wu Lizhong, Wu Xing, Wu Linzhao, Chen Dongdong, Zhang Tao, Zheng Hong, Xiao Xiufeng
Department of Orthopedics, Fuzhou Second Hospital, Fuzhou, Fujian 350007, China.
Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, College of Chemistry and Material Science, Fujian Normal University, Fuzhou, Fujian 350007, China.
ACS Omega. 2024 Jan 19;9(4):4949-4956. doi: 10.1021/acsomega.3c08772. eCollection 2024 Jan 30.
Titanium nanotube (TNT) arrays manufactured via electrochemical anodization have been widely used as local drug carriers due to their excellent biocompatibility and customizable nanotubular structures. However, the uncontrollable and abrupt drug release at the early stage decreases the drug release duration, leading to excessive drug concentration at the implantation site. In this study, a continuous drug delivery system based on TNTs was created. Initially, a basic ultrasound-assisted approach was utilized to deposit a polydopamine (PDA) coating onto TNTs to obtain PDA-modified TNTs. Next, TNTs-PDA were submerged in a calcium chloride solution to include Ca through Ca coordination between the PDA layer's catechol groups. Sodium alendronate (NaAL) was used as a model drug and loaded onto TNTs-PDA-Ca by immersing them in an NaAL solution. In the final step, NaAL was covalently attached to TNTs-PDA-Ca through coordination bonds with Ca. The samples underwent characterization through the use of various techniques, including field emission scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction patterning, X-ray photoelectron spectroscopy, and inductively coupled plasma emission spectrometry. The results indicated that the bioactivity of TNTs improved, and there was an enhancement in drug loading capacity and release performance due to modification with PDA and Ca. Furthermore, acidic conditions can cause significant drug release due to the cleavage of coordination bonds between the drug and Ca ions. Thus, the aforementioned drug delivery system represents a potentially promising approach for achieving sustained and controllable drug release.
通过电化学阳极氧化制备的钛纳米管（TNT）阵列，因其优异的生物相容性和可定制的纳米管结构，已被广泛用作局部药物载体。然而，早期不可控且突然的药物释放会缩短药物释放持续时间，导致植入部位药物浓度过高。在本研究中，创建了一种基于TNTs的持续药物递送系统。首先，采用一种基本的超声辅助方法在TNTs上沉积聚多巴胺（PDA）涂层，以获得PDA修饰的TNTs。接下来，将TNTs-PDA浸入氯化钙溶液中，通过PDA层的邻苯二酚基团之间的钙配位作用引入钙。阿仑膦酸钠（NaAL）用作模型药物，将TNTs-PDA-Ca浸入NaAL溶液中进行负载。在最后一步中，NaAL通过与钙的配位键共价连接到TNTs-PDA-Ca上。通过使用各种技术对样品进行表征，包括场发射扫描电子显微镜、傅里叶变换红外光谱、X射线衍射图谱、X射线光电子能谱和电感耦合等离子体发射光谱。结果表明，TNTs的生物活性得到改善，由于PDA和钙的修饰，药物负载能力和释放性能有所提高。此外，酸性条件会因药物与钙离子之间配位键的断裂而导致大量药物释放。因此，上述药物递送系统是实现持续和可控药物释放的一种潜在的有前景的方法。
