Al Akeel Raid, Mateen Ayesha, Janardhan K, Gupta V C
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Central Research Institute of Unani Medicine, Hyderabad 500 038, India.
Saudi J Biol Sci. 2017 Jan;24(1):11-14. doi: 10.1016/j.sjbs.2015.08.006. Epub 2015 Aug 6.
Herbal medications have been used for relief of symptoms of disease. Regardless of the great advances observed in current medicine in recent decades, plants still make a significant contribution to health care. An alarming increase in bacterial strains resistant to a number of antimicrobial agents demands that a renewed effort be made to seek antibacterial agents effective against pathogenic bacteria resistant to or less sensitive to current antibiotics. Anti-bacterial activity of stem bark was tested against pathogenic and using various solvent extracts. The in vitro anti-bacterial activity was performed by agar well diffusion method and the results were expressed as the average diameter of zone of inhibition of bacterial growth around the well. The ethanol and methanol extracts showed better anti-bacterial activity with zone of inhibition (20-25 mm) when compared with other tested extracts and standard antibiotic Erythromycin (15 mcg) with zone of inhibition (13-14 mm). Using Fisher's exact test of significance difference was found between two Salmonella strains sensitivity patterns against tested extracts ( ⩽ 0.035). Extracts of stem bark also exhibited significant antioxidant activity, thus establishing the extracts as an antioxidant. The results obtained in this study give some scientific support to the stem bark for further investigation of compounds and in future could be used as drug.
草药已被用于缓解疾病症状。尽管近几十年来现代医学取得了巨大进展，但植物仍然对医疗保健做出了重大贡献。对多种抗菌剂耐药的细菌菌株惊人增加，这就要求重新努力寻找对目前抗生素耐药或敏感性较低的病原菌有效的抗菌剂。测试了茎皮对病原菌的抗菌活性，并使用了各种溶剂提取物。通过琼脂孔扩散法进行体外抗菌活性测试，结果以孔周围细菌生长抑制圈的平均直径表示。与其他测试提取物和标准抗生素红霉素（15微克）的抑制圈（13 - 14毫米）相比，乙醇和甲醇提取物表现出更好的抗菌活性，抑制圈为（20 - 25毫米）。使用费舍尔精确检验发现两种沙门氏菌菌株对测试提取物的敏感性模式之间存在显著差异（≤0.035）。茎皮提取物还表现出显著的抗氧化活性，从而确定该提取物为抗氧化剂。本研究获得的结果为进一步研究茎皮中的化合物提供了一些科学支持，未来有可能用作药物。
