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粗树皮提取物浓度对革兰氏阳性和革兰氏阴性细菌病原体的影响。

Effect of Crude Bark Extracts Concentrations against Gram-Positive and Gram-Negative Bacterial Pathogens.

作者信息

Singaravelu Shreelakshmidevi, Sankarapillai Jaikumar, Sasidharn Chandrakumari Abilash, Sinha Pammy

机构信息

Department of Pharmacology, Shri Sathya Sai Medical College and Research Institute, Chennai, Tamil Nadu, India.

Research scholar, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

出版信息

J Pharm Bioallied Sci. 2019 Jan-Mar;11(1):33-37. doi: 10.4103/jpbs.JPBS_150_18.

DOI:10.4103/jpbs.JPBS_150_18
PMID:30906137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6394162/
Abstract

BACKGROUND

Today's pharmaceutical markets are crowded with antibacterial agents, yet their toxicities and resistance are always contentious. is used in India as an age-old treatment for diverse medical conditions. This study was put forth to analyze the antibacterial action of bark extract on different bacterial pathogens.

MATERIALS AND METHODS

bark extract was prepared using Soxhlet extraction method. The bark extract of was screened for antibacterial activity by agar well diffusion assay technique against , , , and Proteus mirabilis. Ciprofloxacin (5 µg per disc) was used as positive control. All assays were carried out under strict aseptic precautions. All the concentrations included were duplicated, and the results obtained were the average of two independent experiments. Broth microdilution method was used to study the minimum inhibitory concentration of the bark extract of .

RESULTS

bark extract has shown antibacterial activity against all concentrations of bark extract, whereas antibacterial activity against was observed at higher concentration of >500 µg/mL. The bark extract of showed zone of clearance against , , and at all concentrations. Zone of inhibition was observed in higher concentrations against .

CONCLUSION

This study has shown that bark extract has a potent antibacterial property against , , , and . Further isolation of bioactive compounds may lead to a new scope in the treatment of bacterial infections.

摘要

背景

当今的制药市场充斥着抗菌剂，但其毒性和耐药性一直存在争议。[植物名称]在印度作为一种古老的疗法用于多种医疗状况。本研究旨在分析[植物名称]树皮提取物对不同细菌病原体的抗菌作用。

材料与方法

采用索氏提取法制备[植物名称]树皮提取物。通过琼脂孔扩散试验技术，针对[细菌名称1]、[细菌名称2]、[细菌名称3]和奇异变形杆菌筛选[植物名称]树皮提取物的抗菌活性。环丙沙星（每片5微克）用作阳性对照。所有试验均在严格的无菌预防措施下进行。所有纳入的浓度均重复，所得结果为两个独立实验的平均值。采用肉汤微量稀释法研究[植物名称]树皮提取物的最低抑菌浓度。

结果

[植物名称]树皮提取物对所有浓度的树皮提取物均显示出抗菌活性，而在>500微克/毫升的较高浓度下观察到对[细菌名称]的抗菌活性。[植物名称]树皮提取物在所有浓度下对[细菌名称1]、[细菌名称2]和[细菌名称3]均显示出抑菌圈。在较高浓度下对[细菌名称]观察到抑菌圈。

结论

本研究表明，[植物名称]树皮提取物对[细菌名称1]、[细菌名称2]、[细菌名称3]和[细菌名称4]具有强大的抗菌特性。生物活性化合物的进一步分离可能为细菌感染的治疗带来新的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a58e/6394162/ebac559690af/JPBS-11-33-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a58e/6394162/04a73ecae181/JPBS-11-33-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a58e/6394162/edeb64223b09/JPBS-11-33-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a58e/6394162/ebac559690af/JPBS-11-33-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a58e/6394162/04a73ecae181/JPBS-11-33-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a58e/6394162/edeb64223b09/JPBS-11-33-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a58e/6394162/ebac559690af/JPBS-11-33-g003.jpg

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