利用RNA干扰调控肝细胞癌中的缺氧肿瘤环境
Regulation of the hypoxic tumor environment in hepatocellular carcinoma using RNA interference.
作者信息
Choi Sung Hoon, Park Jun Yong
机构信息
Division of Bioconvergence Analysis, Drug and Disease Target Group, Korea Basic Science Institute, Daejeon, Korea.
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
出版信息
Cancer Cell Int. 2017 Jan 3;17:3. doi: 10.1186/s12935-016-0374-6. eCollection 2017.
OBJECTIVES
Hypoxia is the condition where tumor cells have been deprived of oxygen and has been shown to have a role of tumor development in the hepatocellular carcinoma (HCC).
METHODS
Using PubMed online database and Google scholar web site, the terms "angiogenesis", "apoptosis", "RNA interference" and/or "hepatocellular carcinoma (HCC)" were searched and analyzed.
RESULTS
The hypoxia inducible factors (HIFs) are transcriptional regulators that affect a homeostatic response to oxidative stress and have been identified as a key transcription activator of angiogenesis, survival, and metabolism. Cytokines, such as IL-8, also controlled endothelia cells survival and angiogenesis. IL-8 was also overexpressed under hypoxia and induced tumor angiogenesis and growth.
CONCLUSION
Therefore, regulation of HIFs and IL-8 controlled the tumor microenvironment in terms of tumor angiogenesis and apoptosis. The review summarizes the results of regulation of the hypoxic tumor environment.
目的
缺氧是肿瘤细胞被剥夺氧气的状态，且已证明其在肝细胞癌（HCC）的肿瘤发展中起作用。
方法
利用PubMed在线数据库和谷歌学术网站，搜索并分析了“血管生成”“细胞凋亡”“RNA干扰”和/或“肝细胞癌（HCC）”等术语。
结果
缺氧诱导因子（HIFs）是影响对氧化应激稳态反应的转录调节因子，已被确定为血管生成、存活和代谢的关键转录激活因子。细胞因子，如白细胞介素-8（IL-8），也控制内皮细胞的存活和血管生成。IL-8在缺氧条件下也会过度表达，并诱导肿瘤血管生成和生长。
结论
因此，HIFs和IL-8的调节在肿瘤血管生成和细胞凋亡方面控制了肿瘤微环境。本综述总结了缺氧肿瘤环境调节的结果。
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