Patil Kalpesh R, Patil Chandragouda R
Department of Pharmacology, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur 425 405, Dist-Dhule, Maharashtra, India.
Department of Pharmacology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425 405, Dist-Dhule, Maharashtra, India.
J Tradit Complement Med. 2016 Apr 4;7(1):86-93. doi: 10.1016/j.jtcme.2016.02.001. eCollection 2017 Jan.
The fruits of are traditionally used in Indian medicine for the treatment of pain and inflammatory conditions. In this study, a fraction of ethyl acetate extract of fruits of (BREAF) was investigated for anti-inflammatory activity in experimental models of acute and chronic inflammation. Activity against acute inflammation was evaluated in inflammogens induced rat paw edema models. Whereas, effect in chronic inflammation was evaluated in cotton pellet granuloma and oxazolone induced delayed type hypersensitivity (DTH) model in mice. The BREAF exhibited dose dependent anti-inflammatory activity in both acute and chronic models at oral doses of 5, 10 and 20 mg/kg. BREAF inhibited both phases of carrageenan induced rat paw inflammation. The reduction in paw inflammation by BREAF was also evident in histamine and serotonin induced inflammation in rats. Effect of BREAF on DTH indicates inhibition of immune mediated inflammation. The reduction in cotton pellet granuloma by BREAF treatment shows inhibition of proliferative changes associated with chronic inflammation. Analysis of BREAF after chromatographic separations showed presence of bartogenic acid as a major constituent. Hence, it is proposed that anti-inflammatory effects of BREAF can be partially attributed to its bartogenic acid content. The minute doses at which this fraction shows anti-inflammatory effects emphasizes the need for further investigations on its efficacy in the immuno-inflammatory conditions.
[植物名称]的果实传统上用于印度医学中治疗疼痛和炎症性疾病。在本研究中，对[植物名称]果实的乙酸乙酯提取物的一个组分（BREAF）在急性和慢性炎症实验模型中的抗炎活性进行了研究。在炎症原诱导的大鼠足爪水肿模型中评估其对急性炎症的活性。而在棉球肉芽肿和恶唑酮诱导的小鼠迟发型超敏反应（DTH）模型中评估其对慢性炎症的作用。BREAF在口服剂量为5、10和20mg/kg时，在急性和慢性模型中均表现出剂量依赖性抗炎活性。BREAF抑制角叉菜胶诱导的大鼠足爪炎症的两个阶段。BREAF对大鼠足爪炎症的减轻在组胺和5-羟色胺诱导的炎症中也很明显。BREAF对DTH的作用表明其抑制免疫介导的炎症。BREAF处理后棉球肉芽肿的减轻表明其抑制了与慢性炎症相关的增殖性变化。色谱分离后对BREAF的分析表明，主要成分是巴托酸。因此，有人提出BREAF的抗炎作用可部分归因于其巴托酸含量。该组分显示抗炎作用的微小剂量强调了对其在免疫炎症性疾病中的疗效进行进一步研究的必要性。
