Gowri P Mangala, Tiwari Ashok K, Ali A Zehra, Rao J Madhusudana
Natural Products Laboratory, Division of Organic Chemistry I, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Phytother Res. 2007 Aug;21(8):796-9. doi: 10.1002/ptr.2176.
Barringtonia racemosa presents a wide range of therapeutic applications. In the course of identifying bioactives from Indian medicinal plants it was observed that the hexane, ethanol and methanol extracts of B. racemosa seeds displayed potent yeast and intestinal alpha-glucosidase inhibitory activities. The methanol extract was found to be superior among them. However, none of the extracts exhibited pancreatic alpha-amylase inhibitory activity, rather the ethanol and methanol extracts accelerated the alpha-amylase enzyme activity. Interestingly, however, bartogenic acid isolated from the methanol extract inhibited alpha-amylase also. This is the first report identifying alpha-glucosidase inhibitory activity in B. racemosa seed extracts and assigning to bartogenic acid an alpha-glucosidase and amylase inhibitory property. The presence of bartogenic acid in B. racemosa seeds as a major compound is also reported for the first time in this communication.
棋盘脚树具有广泛的治疗应用。在从印度药用植物中鉴定生物活性成分的过程中，发现棋盘脚树种子的己烷、乙醇和甲醇提取物具有强大的酵母和肠道α-葡萄糖苷酶抑制活性。其中甲醇提取物表现最优。然而，所有提取物均未表现出胰腺α-淀粉酶抑制活性，相反，乙醇和甲醇提取物加速了α-淀粉酶的酶活性。不过，有趣的是，从甲醇提取物中分离出的巴托格酸也能抑制α-淀粉酶。这是首次报道棋盘脚树种子提取物具有α-葡萄糖苷酶抑制活性，并赋予巴托格酸α-葡萄糖苷酶和淀粉酶抑制特性。本通讯还首次报道了棋盘脚树种子中存在作为主要化合物的巴托格酸。
