Association of Promoter Polymorphisms -765G/C and -1195A/G with Migraine.

BACKGROUND

Migraine is a common debilitating primary headache disorder with current head pain attacks, which contributes to physical activity dysfunctions in chronic pain phase. PGE2 and PGI2 are two important prostaglandins synthesised by enzymes, involved in migraine pain signals. modulation is essential in treatment and pathogenesis of migraine. This study aimed to investigating the association between gene polymorphisms with the risk of migraine susceptibility in migraine patients with related and unrelated parents.

METHODS

This case- control study was based on 100 migraine patients and 100 non-migraine subjects in Bushehr province, Iran in 2013. Genomic DNA of blood samples was extracted and genotyping of and gene variants was investigated by PCR-RFLP method. Statistical analyses were accomplished using the SPSS software package.

RESULTS

There was a significant differences in the frequencies of the and genotypes between migraine patients and controls (≤0.05).

CONCLUSION

, , and genotypes can increase the risk of migraine significantly. As the first study in Iran, we are hopeful to achieve greater results about the relevancy of gene, migraine and pain signals pathway by repeating these experiments on more samples.