Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Tatarstan, Russia.
Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Tatarstan, Russia; RIKEN, Yokohama, Japan.
J Immunol Res. 2016;2016:8528270. doi: 10.1155/2016/8528270. Epub 2016 Dec 5.
Nephropathia epidemica (NE) is a mild form of hemorrhagic fever with renal syndrome. Several reports have demonstrated a severe alteration in lipoprotein metabolism. However, little is known about changes in circulating lipids in NE. The objectives of this study were to evaluate changes in serum total cholesterol, high density cholesterol (HDCL), and triglycerides. In addition to evaluation of serum cytokine activation associations, changes in lipid profile and cytokine activation were determined for gender, thrombocyte counts, and VEGF. Elevated levels of triglycerides and decreased HDCL were observed in NE, while total cholesterol did not differ from controls. High triglycerides were associated with both the lowest thrombocyte counts and high serum VEGF, as well as a high severity score. Additionally, there were higher levels of triglycerides in male than female NE patients. Low triglycerides were associated with upregulation of IFN- and IL-12, suggesting activation of Th1 helper cells. Furthermore, levels of IFN- and IL-12 were increased in patients with lower severity scores, suggesting that a Th1 type immune response is playing protective role in NE. These combined data advance the understanding of NE pathogenesis and indicate a role for high triglycerides in disease severity.
肾综合征出血热（HFRS）是一种温和的出血热肾综合征形式。有几项报告表明，脂蛋白代谢严重改变。然而，对于 NE 患者循环脂质的变化知之甚少。本研究的目的是评估血清总胆固醇、高密度胆固醇（HDCL）和甘油三酯的变化。除了评估血清细胞因子激活的相关性外，还确定了血脂谱和细胞因子激活在性别、血小板计数和 VEGF 方面的变化。NE 患者的甘油三酯水平升高，HDCL 降低，而总胆固醇与对照组无差异。高甘油三酯与血小板计数最低和血清 VEGF 水平高以及严重程度评分高有关。此外，男性 NE 患者的甘油三酯水平高于女性。低甘油三酯与 IFN-和 IL-12 的上调有关，提示 Th1 辅助细胞的激活。此外，严重程度评分较低的患者 IFN-和 IL-12 水平升高，提示 Th1 型免疫反应在 NE 中发挥保护作用。这些综合数据提高了对 NE 发病机制的理解，并表明高甘油三酯在疾病严重程度中起作用。
