Baigildina Asia A, Khaiboullina Svetlana F, Martynova Ekaterina V, Anokhin Vladimir A, Lombardi Vincent C, Rizvanov Albert A
Bashkir State Medical University, Ufa, Republic of Bashkortostan, Russian Federation.
Biomark Med. 2015;9(2):99-107. doi: 10.2217/bmm.14.88. Epub 2014 Oct 14.
Nephropathia epidemica (NE) is a form of hemorrhagic fever with renal syndrome associated with the Puumala virus species of Hantavirus. The pathogenesis of NE is not well understood; therefore, investigating the inflammatory cytokine response to infection may provide useful knowledge in deciphering the pathophysiology of NE.
MATERIALS & METHODS: Using Luminex and ELISA, we analyzed the serum of 137 NE cases and 44 controls to investigate if serum cytokines associate with different clinical presentations.
Serum levels of TNF-α and IL-1β are associated with disease severity while upregulation of IL-6, CXCL10, CCL2 and CCL3 are associated with clinical presentation.
Inflammatory cytokine kinetics associate with the severity and phase of NE. Our data support a role for inflammatory cytokines in the pathophysiology of NE.
流行性肾病（NE）是一种与汉坦病毒属普马拉病毒相关的肾综合征出血热形式。NE的发病机制尚不完全清楚；因此，研究感染后的炎性细胞因子反应可能为解读NE的病理生理学提供有用的知识。
我们使用Luminex和ELISA分析了137例NE患者和44例对照者的血清，以研究血清细胞因子是否与不同的临床表现相关。
TNF-α和IL-1β的血清水平与疾病严重程度相关，而IL-6、CXCL10、CCL2和CCL3的上调与临床表现相关。
炎性细胞因子动力学与NE的严重程度和阶段相关。我们的数据支持炎性细胞因子在NE病理生理学中的作用。
