Nguyen Austin H, Gonzaga Maria I, Lim Victoria M, Adler Michael J, Mitkov Mario V, Cappel Mark A
Creighton University School of Medicine, Omaha, NE, USA.
Department of Biology, Frank R. Seaver College of Science and Engineering, Loyola Marymount University, Los Angeles, CA, USA.
Int J Dermatol. 2017 Jun;56(6):610-616. doi: 10.1111/ijd.13433. Epub 2017 Jan 4.
Shiitake dermatitis is a rare cutaneous reaction to lentinan, a polysaccharide component in the cell walls of shiitake mushrooms (Lentinula edodes). Herein, we systematically review the case report and case series English-language literature on shiitake dermatitis, which refers to a total of 50 patients (38 males, 12 females; mean age: 44.58 years). The majority of cases occurred after the consumption of raw mushrooms, whereas 22% of cases were caused by the eating of lightly or undercooked mushrooms. The most common clinical presentations, localized symptoms, and systemic findings include linear flagellated dermatitis (98%), pruritus (78%), and fever, diarrhea, and mucosal ulcers, respectively. The diagnosis of this entity continues to be based on clinical findings as laboratory abnormalities, and the findings of skin biopsies and patch/prick tests are nonspecific and inconsistent. The condition is self-limiting, resolving in approximately 12.5 d without treatment. Based on the included case reports, it appears that medical treatment may slightly shorten the course of disease (to 9-11 d, varying by therapy) but should be considered on an individual patient basis. However, the treatment of symptoms, reassurance, and the avoidance of re-exposure are sufficient treatment recommendations for this condition.
香菇皮炎是一种对香菇（香菇属）细胞壁中的多糖成分香菇多糖产生的罕见皮肤反应。在此，我们系统回顾了关于香菇皮炎的英文病例报告和病例系列文献，共涉及50例患者（男性38例，女性12例；平均年龄：44.58岁）。大多数病例发生在食用生香菇后，而22%的病例是由食用轻度烹饪或未煮熟的香菇引起的。最常见的临床表现、局部症状和全身表现分别包括线状鞭状皮炎（98%）、瘙痒（78%）以及发热、腹泻和黏膜溃疡。该疾病的诊断仍然基于临床发现，因为实验室检查异常以及皮肤活检和斑贴/点刺试验结果均不具有特异性且不一致。该病具有自限性，未经治疗大约12.5天可痊愈。根据纳入的病例报告，似乎药物治疗可能会略微缩短病程（至9 - 11天，因治疗方法而异），但应根据个体患者情况考虑。然而，针对该疾病，对症治疗、给予安慰以及避免再次接触是足够的治疗建议。
