van den Engel-Hoek L, Knuijt S, van Gerven M H J C, Lagarde M L J, Groothuis J T, de Groot I J M, Janssen M C H
Donders Centre for Neuroscience, Department of Rehabilitation, Radboud University Medical Center, Nijmegen, The Netherlands.
Radboud Center for Mitochondrial Medicine, Nijmegen, The Netherlands.
J Oral Rehabil. 2017 Mar;44(3):155-162. doi: 10.1111/joor.12481. Epub 2017 Jan 30.
In patients with mitochondrial disease, fatigue and muscle problems are the most common complaints. They also experience these complaints during mastication. To measure endurance of continuous mastication in patients with mitochondrial diseases, the 6-min mastication test (6MMT) was developed. This study included the collection of normal data for the 6MMT in a healthy population (children and adults). During 6 min of continuous mastication on a chew tube chewing cycles per minute, total amount of chewing cycles and the difference between minute 1 (M ) and minute 6 (M ) were collected in 271 healthy participants (5-80 years old). These results were compared with those of nine paediatric and 25 adult patients with a mitochondrial disease. Visual analogue scale (VAS) scores were collected directly after the test and after 5 min. A qualitative rating was made on masticatory movements. The reproducibility of the 6MMT in the healthy population with an interval of approximately 2 weeks was good. The inter-rater reliability for the observations was excellent. The patient group demonstrated lower total amount of chewing cycles or had greater differences between M and M . The 6MMT is a reliable and objective test to assess endurance of continuous chewing. It demonstrates the ability of healthy children and adults to chew during 6 min with a highly stable frequency of mastication movements. The test may give an explanation for the masticatory problems in patient groups, who are complaining of pain and fatigue during mastication.
在线粒体疾病患者中，疲劳和肌肉问题是最常见的主诉。他们在咀嚼时也会出现这些症状。为了测量线粒体疾病患者持续咀嚼的耐力，开发了6分钟咀嚼试验（6MMT）。本研究包括收集健康人群（儿童和成人）6MMT的正常数据。在使用咀嚼管持续咀嚼6分钟的过程中，记录每分钟的咀嚼周期，收集了271名健康参与者（5至80岁）的总咀嚼周期数以及第1分钟（M1）和第6分钟（M6）之间的差异。将这些结果与9名儿科线粒体疾病患者和25名成线粒体疾病患者的结果进行比较。在试验结束后和5分钟后直接收集视觉模拟量表（VAS）评分。对咀嚼运动进行了定性评分。在健康人群中，间隔约2周进行的6MMT重复性良好。观察者间对观察结果的可靠性极佳。患者组的总咀嚼周期数较低，或M1和M6之间的差异较大。6MMT是一种评估持续咀嚼耐力的可靠且客观的测试。它显示了健康儿童和成人在6分钟内以高度稳定的咀嚼运动频率进行咀嚼的能力。该测试可能为在咀嚼时抱怨疼痛和疲劳的患者群体的咀嚼问题提供一种解释。
