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Bone and Soft-Tissue Sarcoma: A New Target for Telomerase-Specific Oncolytic Virotherapy.骨肉瘤和软组织肉瘤：端粒酶特异性溶瘤病毒疗法的新靶点。
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本文引用的文献

1
Vemurafenib-resistant BRAF-V600E-mutated melanoma is regressed by MEK-targeting drug trametinib, but not cobimetinib in a patient-derived orthotopic xenograft (PDOX) mouse model.在患者来源的原位异种移植（PDOX）小鼠模型中，针对MEK的药物曲美替尼可使对维莫非尼耐药的BRAF-V600E突变型黑色素瘤消退，但考比替尼则不能。
Oncotarget. 2016 Nov 1;7(44):71737-71743. doi: 10.18632/oncotarget.12328.
2
Melanin content in melanoma metastases affects the outcome of radiotherapy.黑色素瘤转移灶中的黑色素含量会影响放射治疗的效果。
Oncotarget. 2016 Apr 5;7(14):17844-53. doi: 10.18632/oncotarget.7528.
3
Improved Resection and Outcome of Colon-Cancer Liver Metastasis with Fluorescence-Guided Surgery Using In Situ GFP Labeling with a Telomerase-Dependent Adenovirus in an Orthotopic Mouse Model.在原位小鼠模型中，使用端粒酶依赖性腺病毒进行原位绿色荧光蛋白标记的荧光引导手术改善结肠癌肝转移的切除及预后
PLoS One. 2016 Feb 5;11(2):e0148760. doi: 10.1371/journal.pone.0148760. eCollection 2016.
4
Adenoviral targeting of malignant melanoma for fluorescence-guided surgery prevents recurrence in orthotopic nude-mouse models.腺病毒靶向恶性黑色素瘤用于荧光引导手术可预防原位裸鼠模型中的复发。
Oncotarget. 2016 Apr 5;7(14):18558-72. doi: 10.18632/oncotarget.6670.
5
Targeted Photodynamic Virotherapy Armed with a Genetically Encoded Photosensitizer.携带基因编码光敏剂的靶向光动力病毒疗法
Mol Cancer Ther. 2016 Jan;15(1):199-208. doi: 10.1158/1535-7163.MCT-15-0344. Epub 2015 Dec 1.
6
Eradication of osteosarcoma by fluorescence-guided surgery with tumor labeling by a killer-reporter adenovirus.通过杀伤报告腺病毒标记肿瘤的荧光引导手术根除骨肉瘤
J Orthop Res. 2016 May;34(5):836-44. doi: 10.1002/jor.23073. Epub 2015 Nov 3.
7
Developing strategies to predict photodynamic therapy outcome: the role of melanoma microenvironment.制定预测光动力治疗效果的策略：黑色素瘤微环境的作用。
Tumour Biol. 2015 Dec;36(12):9127-36. doi: 10.1007/s13277-015-4059-x. Epub 2015 Sep 29.
8
Precise navigation surgery of tumours in the lung in mouse models enabled by in situ fluorescence labelling with a killer-reporter adenovirus.通过原位荧光标记杀伤报告腺病毒，实现了小鼠模型肺部肿瘤的精确导航手术。
BMJ Open Respir Res. 2015 Sep 7;2(1):e000096. doi: 10.1136/bmjresp-2015-000096. eCollection 2015.
9
Targeting tumors with a killer-reporter adenovirus for curative fluorescence-guided surgery of soft-tissue sarcoma.用一种杀伤性报告腺病毒靶向肿瘤用于软组织肉瘤的治愈性荧光引导手术。
Oncotarget. 2015 May 30;6(15):13133-48. doi: 10.18632/oncotarget.3811.
10
Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus.使用杀伤报告腺病毒选择性标记的高侵袭性多形性胶质母细胞瘤的实验性治疗性荧光引导手术
Mol Ther. 2015 Jul;23(7):1182-1188. doi: 10.1038/mt.2015.63. Epub 2015 Apr 21.

通过靶向含Killer-Red的端粒酶依赖性腺病毒在体外和体内根除黑色素瘤。

Eradication of melanoma in vitro and in vivo via targeting with a Killer-Red-containing telomerase-dependent adenovirus.

作者信息

Takehara Kiyoto, Yano Shuya, Tazawa Hiroshi, Kishimoto Hiroyuki, Narii Nobuhiro, Mizuguchi Hiroyuki, Urata Yasuo, Kagawa Shunsuke, Fujiwara Toshiyoshi, Hoffman Robert M

机构信息

a AntiCancer, Inc. , San Diego , CA , USA.

b Department of Surgery , University of California San Diego , San Diego , CA , USA.

出版信息

Cell Cycle. 2017 Aug 18;16(16):1502-1508. doi: 10.1080/15384101.2016.1249548. Epub 2017 Jan 5.

DOI:10.1080/15384101.2016.1249548
PMID:28055296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5584861/
Abstract

Melanoma is a highly recalcitrant cancer and transformative therapy is necessary for the cure of this disease. We recently developed a telomerase-dependent adenovirus containing the fluorescent protein Killer-Red. In the present report, we first determined the efficacy of Killer-Red adenovirus combined with laser irradiation on human melanoma cell lines in vitro. Cell viability of human melanoma cells was reduced in a dose-dependent and irradiation-time-dependent manner. We used an intradermal xenografted melanoma model in nude mice to determine efficacy of the Killer-Red adenovirus. Intratumoral injection of Killer-Red adenovirus, combined with laser irradiation, eradicated the melanoma indicating the potential of a new paradigm of cancer therapy.

摘要

黑色素瘤是一种极具顽固性的癌症，变革性疗法对于治愈这种疾病至关重要。我们最近研发了一种携带荧光蛋白Killer-Red的端粒酶依赖性腺病毒。在本报告中，我们首先在体外确定了Killer-Red腺病毒与激光照射联合对人黑色素瘤细胞系的疗效。人黑色素瘤细胞的活力以剂量依赖性和照射时间依赖性方式降低。我们使用裸鼠皮内异种移植黑色素瘤模型来确定Killer-Red腺病毒的疗效。瘤内注射Killer-Red腺病毒并结合激光照射，根除了黑色素瘤，这表明了一种新的癌症治疗模式的潜力。