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在原位小鼠模型中，使用端粒酶依赖性腺病毒进行原位绿色荧光蛋白标记的荧光引导手术改善结肠癌肝转移的切除及预后

Improved Resection and Outcome of Colon-Cancer Liver Metastasis with Fluorescence-Guided Surgery Using In Situ GFP Labeling with a Telomerase-Dependent Adenovirus in an Orthotopic Mouse Model.

作者信息

Yano Shuya, Takehara Kiyoto, Miwa Shinji, Kishimoto Hiroyuki, Hiroshima Yukihiko, Murakami Takashi, Urata Yasuo, Kagawa Shunsuke, Bouvet Michael, Fujiwara Toshiyoshi, Hoffman Robert M

机构信息

AntiCancer, Inc., San Diego, CA, United States of America.

Department of Surgery, University of California San Diego, San Diego, CA, United States of America.

出版信息

PLoS One. 2016 Feb 5;11(2):e0148760. doi: 10.1371/journal.pone.0148760. eCollection 2016.

DOI:10.1371/journal.pone.0148760
PMID:26849435
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4743860/
Abstract

Fluorescence-guided surgery (FGS) of cancer is an area of intense development. In the present report, we demonstrate that the telomerase-dependent green fluorescent protein (GFP)-containing adenovirus OBP-401 could label colon-cancer liver metastasis in situ in an orthotopic mouse model enabling successful FGS. OBP-401-GFP-labeled liver metastasis resulted in complete resection with FGS, in contrast, conventional bright-light surgery (BLS) did not result in complete resection of the metastasis. OBP-401-FGS reduced the recurrence rate and prolonged over-all survival compared with BLS. In conclusion, adenovirus OBP-401 is a powerful tool to label liver metastasis in situ with GFP which enables its complete resection, not possible with conventional BLS.

摘要

癌症的荧光引导手术（FGS）是一个正在蓬勃发展的领域。在本报告中，我们证明了含端粒酶依赖性绿色荧光蛋白（GFP）的腺病毒OBP - 401能够在原位小鼠模型中标记结肠癌肝转移灶，从而实现成功的荧光引导手术。与传统的明视手术（BLS）不同，OBP - 401 - GFP标记的肝转移灶通过荧光引导手术实现了完全切除。与BLS相比，OBP - 401荧光引导手术降低了复发率并延长了总体生存期。总之，腺病毒OBP - 401是一种用GFP原位标记肝转移灶的强大工具，能够实现其完全切除，而这是传统明视手术无法做到的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d43f/4743860/79b187ee0221/pone.0148760.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d43f/4743860/857a63e8e0d0/pone.0148760.g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d43f/4743860/97cfa13ff49d/pone.0148760.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d43f/4743860/623b860c66fe/pone.0148760.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d43f/4743860/617e1827a59a/pone.0148760.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d43f/4743860/1b641c745671/pone.0148760.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d43f/4743860/79b187ee0221/pone.0148760.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d43f/4743860/857a63e8e0d0/pone.0148760.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d43f/4743860/d54be9dd3c78/pone.0148760.g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d43f/4743860/79b187ee0221/pone.0148760.g008.jpg

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