使用杀伤报告腺病毒选择性标记的高侵袭性多形性胶质母细胞瘤的实验性治疗性荧光引导手术
Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus.
作者信息
Yano Shuya, Miwa Shinji, Kishimoto Hiroyuki, Toneri Makoto, Hiroshima Yukihiko, Yamamoto Mako, Bouvet Michael, Urata Yasuo, Tazawa Hiroshi, Kagawa Shunsuke, Fujiwara Toshiyoshi, Hoffman Robert M
机构信息
AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA; Department of Gastroenterological Surgery, Okayama University, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
AntiCancer, Inc., San Diego, California, USA; Department of Surgery, University of California San Diego, San Diego, California, USA.
出版信息
Mol Ther. 2015 Jul;23(7):1182-1188. doi: 10.1038/mt.2015.63. Epub 2015 Apr 21.
Abstract
Fluorescence-guided surgery (FGS) of cancer is an area of intense current interest. However, although benefits have been demonstrated with FGS, curative strategies need to be developed. Glioblastoma multiforme (GBM) is one of the most invasive of cancers and is not totally resectable using standard bright-light surgery (BLS) or current FGS strategies. We report here a curative strategy for FGS of GBM. In this study, telomerase-dependent adenovirus OBP-401 infection brightly and selectively labeled GBM with green fluorescent protein (GFP) for FGS in orthotopic nude mouse models. OBP-401-based FGS enabled curative resection of GBM without recurrence for at least 150 days, compared to less than 30 days with BLS.
摘要
癌症的荧光引导手术（FGS）是当前备受关注的领域。然而，尽管FGS已显示出益处，但仍需制定治愈策略。多形性胶质母细胞瘤（GBM）是侵袭性最强的癌症之一，使用标准的明视手术（BLS）或当前的FGS策略都无法完全切除。我们在此报告一种GBM的FGS治愈策略。在本研究中，端粒酶依赖性腺病毒OBP-401感染以绿色荧光蛋白（GFP）明亮且选择性地标记原位裸鼠模型中的GBM用于FGS。与BLS术后不到30天相比，基于OBP-401的FGS能够实现GBM的根治性切除且至少150天无复发。
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