iCAP: An Individualized Model Combining Gaze Parameters and Image-Based Features to Predict Radiologists' Decisions While Reading Mammograms.

This study introduces an individualized tool for identifying mammogram interpretation errors, called eye-Computer Assisted Perception (iCAP). iCAP consists of two modules, one which processes areas marked by radiologists as suspicious for cancer and classifies these as False Positive (FP) or True Positive (TP) decisions, while the second module classifies fixated but not marked locations as False Negative (FN) or True-Negative (TN) decisions. iCAP relies on both radiologists' gaze-related parameters, extracted from eye tracking data, and image-based features. In order to evaluate iCAP, eye tracking data from eight breast radiologists reading 120 two-view digital mammograms were collected. Fifty-nine cases had biopsy proven cancer. For each radiologist, a user-specific support vector machine model was built to classify the radiologist' s reported areas as TPs or FPs and fixated locations as TNs or FNs. The performances of the classifiers were evaluated by utilizing leave-one-out cross validation. iCAP was tested retrospectively in a simulated scenario in which it was assumed that the radiologists would accept all iCAP decisions. Using iCAP led to an average increase of 12%±6% in the number of correctly localized cancer and an average decrease of 44.5%±22.7% in the number of FPs per image.