Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190, P. R. China.
Department of Chemistry, Purdue University , West Lafayette, Indiana 47907-2084, United States.
Langmuir. 2017 Jan 31;33(4):1116-1120. doi: 10.1021/acs.langmuir.6b04469. Epub 2017 Jan 18.
Infections of antibiotic-resistant pathogens have caused a series of public health crises across the world. According to the latest published reports, an antibiotic switch has been recognized as a potential strategy to control antibacterial activity for combating this serious drug resistance. Thus, it is anticipated that more effective antibiotic switches should be obtained by further exploring the developed strategies. Here, we report an improved pretreatment strategy using a surfactant (Triton X-100) for constructing an effective supramolecular antibiotic switch based on a poly(fluorene-co-phenylene) derivative (PFP) and cucurbit[7]uril (CB[7]), which can regulate the aggregation state of polymers before the supramolecular self-assembly process occurs. Triton X-100 can regulate the aggregation states of conjugated polymers, which is used to successfully realize the reversible control of bactericidal activity of PFP in the dark and under white light irradiation by supramolecular assembly/disassembly between PFP and CB[7]. Specialized antibiotic switches are significantly important to fight pathogenic infections and solve the drug resistance crisis in the future.
抗生素耐药病原体的感染在全球范围内引发了一系列公共卫生危机。根据最新发表的报告，抗生素转换已被认为是控制抗菌活性以应对这种严重耐药性的一种潜在策略。因此，预计通过进一步探索已开发的策略，可以获得更有效的抗生素转换。在这里，我们报告了一种使用表面活性剂（Triton X-100）的改进预处理策略，用于构建基于聚（芴-共-苯）衍生物（PFP）和瓜环[7]（CB[7]）的有效超分子抗生素开关，该开关可以调节超分子自组装过程之前聚合物的聚集态。Triton X-100 可以调节共轭聚合物的聚集态，成功地实现了 PFP 在黑暗中和在白光照射下杀菌活性的可逆控制，这是通过 PFP 和 CB[7]之间的超分子组装/解组装来实现的。专用抗生素开关对于对抗致病感染和解决未来的耐药危机具有重要意义。
