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一种共轭聚电解质通过单线态氧生成诱导白光诱导的细胞凋亡。

White light-induced cell apoptosis by a conjugated polyelectrolyte through singlet oxygen generation.

作者信息

Liang Jiamei, Wu Pan, Tan Chunyan, Jiang Yuyang

机构信息

Department of Chemistry, Tsinghua University Beijing 100084 P. R. China.

The State Key Laboratory of Chemical Oncogenomics, The Graduate School at Shenzhen, Tsinghua University Shenzhen 518055 P. R. China

出版信息

RSC Adv. 2018 Mar 1;8(17):9218-9222. doi: 10.1039/c8ra00774h. eCollection 2018 Feb 28.

DOI:10.1039/c8ra00774h
PMID:35541876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9078657/
Abstract

A cationic conjugated polyelectrolyte (CPE) PPET3 with a poly(-phenylene ethynylene terthiophene) backbone and quaternary ammonium side chains was designed and synthesized. It serves as an efficient photosensitizer for photodynamic therapy under white light irradiation and induces cell death through the mitochondrial apoptosis pathway.

摘要

设计并合成了一种具有聚（亚苯基乙炔基噻吩）主链和季铵侧链的阳离子共轭聚电解质（CPE）PPET3。它在白光照射下作为光动力疗法的有效光敏剂，并通过线粒体凋亡途径诱导细胞死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ede4/9078657/bf928558abe7/c8ra00774h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ede4/9078657/2b095926c8df/c8ra00774h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ede4/9078657/c92df9d1288f/c8ra00774h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ede4/9078657/ffb66f17a0fb/c8ra00774h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ede4/9078657/7b7cd41325b0/c8ra00774h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ede4/9078657/bf928558abe7/c8ra00774h-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ede4/9078657/2b095926c8df/c8ra00774h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ede4/9078657/c92df9d1288f/c8ra00774h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ede4/9078657/ffb66f17a0fb/c8ra00774h-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ede4/9078657/7b7cd41325b0/c8ra00774h-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ede4/9078657/bf928558abe7/c8ra00774h-f4.jpg

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