Gong Xue-Peng, Sun Yuan-Yuan, Chen Wei, Guo Xia, Guan Jian-Kun, Li Dong-Yan, Du Guang
Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095# Hangkong Road, Wuhan, 430030, People's Republic of China.
BMC Complement Altern Med. 2017 Jan 5;17(1):20. doi: 10.1186/s12906-016-1527-9.
In Shaanxi province, China, the aqueous extract of Rubia cordifolia's aerial part (AERCAP) is traditionally used to manage diarrhea. However, there is no scientific evidence to verify the safety and efficacy of its use. The aim of this study was to investigate the anti-diarrheal and anti-inflammatory effects of AERCAP by using a rodent model.
The anti-diarrheal effects were studied by senna leaf-induced diarrheal and intestinal transit experiments in mice. The anti-inflammatory activity was investigated by trinitrobenzenesulfonic acid (TNBS)-induced colonic inflammation in rats.
The results indicated that AERCAP delayed the onset of semi-solid feces, reduced the evacuation index (EI) in senna leaf-induced diarrheal in mice, and inhibited the propulsive movement in castor oil-induced intestinal transit but not in the normal intestinal transit test. The results were compared with the standard anti-diarrheal drug loperamide. Additionally, oral treatment with AERCAP significantly decreased the macroscopic damage area, improved the microscopic structure, and reduced the malondialdehyde (MDA) content, IL-1β and TNF-α levels in colonic tissue compared with the TNBS control group in rats.
AERCAP exhibited anti-diarrheal and anti-inflammatory activities in a rodent model. The study validated the traditional use of the plant in Chinese herbal medicine as a valuable natural remedy for the treatment of diarrhea.
在中国陕西省，茜草地上部分的水提取物（AERCAP）传统上用于治疗腹泻。然而，尚无科学证据证实其使用的安全性和有效性。本研究的目的是通过啮齿动物模型研究AERCAP的止泻和抗炎作用。
通过番泻叶诱导的小鼠腹泻和肠道转运实验研究其止泻作用。通过三硝基苯磺酸（TNBS）诱导的大鼠结肠炎症研究其抗炎活性。
结果表明，AERCAP延迟了小鼠半固体粪便的出现，降低了番泻叶诱导的小鼠腹泻中的排空指数（EI），并抑制了蓖麻油诱导的肠道转运中的推进运动，但在正常肠道转运试验中未观察到这种作用。结果与标准止泻药物洛哌丁胺进行了比较。此外，与大鼠TNBS对照组相比，口服AERCAP显著降低了结肠组织的宏观损伤面积，改善了微观结构，并降低了丙二醛（MDA）含量、IL-1β和TNF-α水平。
AERCAP在啮齿动物模型中表现出止泻和抗炎活性。该研究证实了该植物在传统中药中作为治疗腹泻的宝贵天然药物的用途。
